TY - JOUR
T1 - Lack of association between ORAI1/CRACM1 Gene Polymorphisms and Kawasaki disease in the Taiwanese children
AU - Kuo, Ho Chang
AU - Lin, Ying Jui
AU - Juo, Suh Hang Hank
AU - Hsu, Yu Wen
AU - Chen, Wei Chiao
AU - Yang, Kuender D.
AU - Liang, Chi Di
AU - Yang, Shengyu
AU - Chao, Mei Chyn
AU - Yu, Hong Ren
AU - Wang, Shouyan
AU - Lin, Li Yan
AU - Chang, Wei Chiao
PY - 2011/8
Y1 - 2011/8
N2 - Objective Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/ CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. Materials and Methods A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/ CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. Results No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. Conclusions This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.
AB - Objective Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/ CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. Materials and Methods A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/ CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. Results No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. Conclusions This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.
KW - Coronary artery lesions
KW - Intravenous immunoglobulin
KW - Kawasaki disease
KW - ORAI1/CRACM1
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U2 - 10.1007/s10875-011-9524-8
DO - 10.1007/s10875-011-9524-8
M3 - Article
C2 - 21487896
AN - SCOPUS:80555155602
SN - 0271-9142
VL - 31
SP - 650
EP - 655
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
IS - 4
ER -