Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation

Fu Lun Chen; Li Dan Shang; Yen Chung Lin; Bo Yen Chang; Yu Cheng Hsiao

doi:10.3390/bios13010060

Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation

Fu Lun Chen, Li Dan Shang, Yen Chung Lin, Bo Yen Chang, Yu Cheng Hsiao

Research output: Contribution to journal › Article › peer-review

Abstract

The early diagnosis of acute myocardial infarction is difficult in patients with nondiagnostic characteristics. Acute myocardial infarction with chest pain is associated with increased mortality. This study developed a portable test kit based on cholesteric liquid crystals (CLCs) for the rapid detection of AMI through eye observation at home. The test kit was established on dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride-coated substrates covered by a CLC-binding antibody. Cardiac troponin I (cTnI) is a major biomarker of myocardial cellular injury in human blood. The data showed that the concentration of cTnI was related to light transmittance in a positive way. The proposed CLC test kit can be operated with a smartphone; therefore, it has high potential for use as a point-of-care device for home testing. Moreover, the CLC test kit is an effective and innovative device for the rapid testing of acute myocardial infarction-related diseases through eye observation, spectrometer, or even smartphone applications.

Original language	English
Article number	60
Journal	Biosensors
Volume	13
Issue number	1
DOIs	https://doi.org/10.3390/bios13010060
Publication status	Published - Jan 2023

Keywords

acute myocardial infarction rapid test
cardiac troponin I (cTnI)
cholesteric liquid crystal

ASJC Scopus subject areas

Analytical Chemistry
Biotechnology
Biomedical Engineering
Instrumentation
Engineering (miscellaneous)
Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/bios13010060

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title = "Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation",

abstract = "The early diagnosis of acute myocardial infarction is difficult in patients with nondiagnostic characteristics. Acute myocardial infarction with chest pain is associated with increased mortality. This study developed a portable test kit based on cholesteric liquid crystals (CLCs) for the rapid detection of AMI through eye observation at home. The test kit was established on dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride-coated substrates covered by a CLC-binding antibody. Cardiac troponin I (cTnI) is a major biomarker of myocardial cellular injury in human blood. The data showed that the concentration of cTnI was related to light transmittance in a positive way. The proposed CLC test kit can be operated with a smartphone; therefore, it has high potential for use as a point-of-care device for home testing. Moreover, the CLC test kit is an effective and innovative device for the rapid testing of acute myocardial infarction-related diseases through eye observation, spectrometer, or even smartphone applications.",

keywords = "acute myocardial infarction rapid test, cardiac troponin I (cTnI), cholesteric liquid crystal",

author = "Chen, {Fu Lun} and Shang, {Li Dan} and Lin, {Yen Chung} and Chang, {Bo Yen} and Hsiao, {Yu Cheng}",

note = "Funding Information: This research work was financially supported by grants from the Taipei Medical University Hospital, Taipei Medical University—Taipei Medical University Hospital (111TMU-TMUH-01-3) and Taipei Medical University—Wan Fang Hospital, Taiwan, under grant no. (111TMU-WFH-23). Publisher Copyright: {\textcopyright} 2022 by the authors.",

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doi = "10.3390/bios13010060",

language = "English",

volume = "13",

journal = "Biosensors",

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AU - Shang, Li Dan

AU - Lin, Yen Chung

AU - Chang, Bo Yen

AU - Hsiao, Yu Cheng

N1 - Funding Information: This research work was financially supported by grants from the Taipei Medical University Hospital, Taipei Medical University—Taipei Medical University Hospital (111TMU-TMUH-01-3) and Taipei Medical University—Wan Fang Hospital, Taiwan, under grant no. (111TMU-WFH-23). Publisher Copyright: © 2022 by the authors.

PY - 2023/1

Y1 - 2023/1

N2 - The early diagnosis of acute myocardial infarction is difficult in patients with nondiagnostic characteristics. Acute myocardial infarction with chest pain is associated with increased mortality. This study developed a portable test kit based on cholesteric liquid crystals (CLCs) for the rapid detection of AMI through eye observation at home. The test kit was established on dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride-coated substrates covered by a CLC-binding antibody. Cardiac troponin I (cTnI) is a major biomarker of myocardial cellular injury in human blood. The data showed that the concentration of cTnI was related to light transmittance in a positive way. The proposed CLC test kit can be operated with a smartphone; therefore, it has high potential for use as a point-of-care device for home testing. Moreover, the CLC test kit is an effective and innovative device for the rapid testing of acute myocardial infarction-related diseases through eye observation, spectrometer, or even smartphone applications.

AB - The early diagnosis of acute myocardial infarction is difficult in patients with nondiagnostic characteristics. Acute myocardial infarction with chest pain is associated with increased mortality. This study developed a portable test kit based on cholesteric liquid crystals (CLCs) for the rapid detection of AMI through eye observation at home. The test kit was established on dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride-coated substrates covered by a CLC-binding antibody. Cardiac troponin I (cTnI) is a major biomarker of myocardial cellular injury in human blood. The data showed that the concentration of cTnI was related to light transmittance in a positive way. The proposed CLC test kit can be operated with a smartphone; therefore, it has high potential for use as a point-of-care device for home testing. Moreover, the CLC test kit is an effective and innovative device for the rapid testing of acute myocardial infarction-related diseases through eye observation, spectrometer, or even smartphone applications.

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Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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