Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

Yu Jen Kuo; Ping Chun Hsiao; Li Jie Zhang; Ming Der Wu; Yu Han Liang; Hsiu O. Ho; Yao Haur Kuo

doi:10.1021/np900019n

Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

Yu Jen Kuo, Ping Chun Hsiao, Li Jie Zhang, Ming Der Wu, Yu Han Liang, Hsiu O. Ho, Yao Haur Kuo

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μ M against several human tumor cell lines.

Original language	English
Pages (from-to)	1097-1101
Number of pages	5
Journal	Journal of Natural Products
Volume	72
Issue number	6
DOIs	https://doi.org/10.1021/np900019n
Publication status	Published - Jun 26 2009

ASJC Scopus subject areas

Drug Discovery
Analytical Chemistry
Molecular Medicine
Complementary and alternative medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry

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title = "Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages",

abstract = "Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μ M against several human tumor cell lines.",

author = "Kuo, {Yu Jen} and Hsiao, {Ping Chun} and Zhang, {Li Jie} and Wu, {Ming Der} and Liang, {Yu Han} and Ho, {Hsiu O.} and Kuo, {Yao Haur}",

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T1 - Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

AU - Kuo, Yu Jen

AU - Hsiao, Ping Chun

AU - Zhang, Li Jie

AU - Wu, Ming Der

AU - Liang, Yu Han

AU - Ho, Hsiu O.

AU - Kuo, Yao Haur

PY - 2009/6/26

Y1 - 2009/6/26

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AB - Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μ M against several human tumor cell lines.

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Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

Abstract

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