K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea

Han Pin Kuo; Juliette A.L. Rohde; Peter J. Barnes; Duncan F. Rogers

doi:10.1016/0014-2999(92)90043-4

K⁺ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea

Han Pin Kuo
, Juliette A.L. Rohde
, Peter J. Barnes
, Duncan F. Rogers

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A potassium (K⁺) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit metacholine- or substance P-induced goblet cell secretion which suggests that K⁺ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves.

Original language	English
Pages (from-to)	297-299
Number of pages	3
Journal	European Journal of Pharmacology
Volume	215
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(92)90043-4
Publication status	Published - May 14 1992
Externally published	Yes

Keywords

Goblet cell secretion
K channel activators

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(92)90043-4

Cite this

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title = "K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea",

abstract = "A potassium (K+) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit metacholine- or substance P-induced goblet cell secretion which suggests that K+ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves.",

keywords = "Goblet cell secretion, K channel activators",

author = "Kuo, \{Han Pin\} and Rohde, \{Juliette A.L.\} and Barnes, \{Peter J.\} and Rogers, \{Duncan F.\}",

year = "1992",

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T1 - K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea

AU - Kuo, Han Pin

AU - Rohde, Juliette A.L.

AU - Barnes, Peter J.

AU - Rogers, Duncan F.

PY - 1992/5/14

Y1 - 1992/5/14

N2 - A potassium (K+) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit metacholine- or substance P-induced goblet cell secretion which suggests that K+ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves.

AB - A potassium (K+) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit metacholine- or substance P-induced goblet cell secretion which suggests that K+ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves.

KW - Goblet cell secretion

KW - K channel activators

UR - https://www.scopus.com/pages/publications/0026551056

UR - https://www.scopus.com/pages/publications/0026551056#tab=citedBy

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EP - 299

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JF - European Journal of Pharmacology

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