Kleine-Levin syndrome and psychosis: Observation from an unusual case

Mong Liang Lu; Hsing Cheng Liu; Chin Hung Chen; Shing Ming Sung

Kleine-Levin syndrome and psychosis: Observation from an unusual case

Mong Liang Lu, Hsing Cheng Liu, Chin Hung Chen, Shing Ming Sung

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: This study evaluated the possible pathologic relation between Kleine-Levin syndrome (KLS) and mood disorders. Background: A 28-year-old man with a remote history of KLS had the sudden onset of a manic episode with psychotic features after the end of hypersomnolence. Method: The patient received an extensive laboratory examination, including single photon emission computed tomography and magnetic resonance imaging. Results: Single photon emission computed tomography showed decreased tracer perfusion in the basal ganglion, hypothalamus, and right frontotemporal region. Magnetic resonance imaging revealed a cystic lesion in the pineal region. Conclusions: Hypothalamic dysfunction has been described in KLS and mood disorders, but pineal gland dysfunction has been mentioned only rarely. The clinical and neuroimaging findings suggest the need for further study of KLS.

Original language	English
Pages (from-to)	140-142
Number of pages	3
Journal	Neuropsychiatry, Neuropsychology and Behavioral Neurology
Volume	13
Issue number	2
Publication status	Published - Apr 2000
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Neurology
Psychiatry and Mental health
General Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Kleine-Levin syndrome and psychosis: Observation from an unusual case",

abstract = "Objective: This study evaluated the possible pathologic relation between Kleine-Levin syndrome (KLS) and mood disorders. Background: A 28-year-old man with a remote history of KLS had the sudden onset of a manic episode with psychotic features after the end of hypersomnolence. Method: The patient received an extensive laboratory examination, including single photon emission computed tomography and magnetic resonance imaging. Results: Single photon emission computed tomography showed decreased tracer perfusion in the basal ganglion, hypothalamus, and right frontotemporal region. Magnetic resonance imaging revealed a cystic lesion in the pineal region. Conclusions: Hypothalamic dysfunction has been described in KLS and mood disorders, but pineal gland dysfunction has been mentioned only rarely. The clinical and neuroimaging findings suggest the need for further study of KLS.",

author = "Lu, {Mong Liang} and Liu, {Hsing Cheng} and Chen, {Chin Hung} and Sung, {Shing Ming}",

year = "2000",

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journal = "Neuropsychiatry, Neuropsychology and Behavioral Neurology",

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T2 - Observation from an unusual case

AU - Lu, Mong Liang

AU - Liu, Hsing Cheng

AU - Chen, Chin Hung

AU - Sung, Shing Ming

PY - 2000/4

Y1 - 2000/4

N2 - Objective: This study evaluated the possible pathologic relation between Kleine-Levin syndrome (KLS) and mood disorders. Background: A 28-year-old man with a remote history of KLS had the sudden onset of a manic episode with psychotic features after the end of hypersomnolence. Method: The patient received an extensive laboratory examination, including single photon emission computed tomography and magnetic resonance imaging. Results: Single photon emission computed tomography showed decreased tracer perfusion in the basal ganglion, hypothalamus, and right frontotemporal region. Magnetic resonance imaging revealed a cystic lesion in the pineal region. Conclusions: Hypothalamic dysfunction has been described in KLS and mood disorders, but pineal gland dysfunction has been mentioned only rarely. The clinical and neuroimaging findings suggest the need for further study of KLS.

AB - Objective: This study evaluated the possible pathologic relation between Kleine-Levin syndrome (KLS) and mood disorders. Background: A 28-year-old man with a remote history of KLS had the sudden onset of a manic episode with psychotic features after the end of hypersomnolence. Method: The patient received an extensive laboratory examination, including single photon emission computed tomography and magnetic resonance imaging. Results: Single photon emission computed tomography showed decreased tracer perfusion in the basal ganglion, hypothalamus, and right frontotemporal region. Magnetic resonance imaging revealed a cystic lesion in the pineal region. Conclusions: Hypothalamic dysfunction has been described in KLS and mood disorders, but pineal gland dysfunction has been mentioned only rarely. The clinical and neuroimaging findings suggest the need for further study of KLS.

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Kleine-Levin syndrome and psychosis: Observation from an unusual case

Abstract

ASJC Scopus subject areas

UN SDGs

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