Kinetic studies of the photochemical decomposition of alkannin/shikonin enantiomers

Fu An Chen; Hui Wen Cheng; An-Bang Wu; Hsing Chu Hsu; Chau Yang Chen

doi:10.1248/cpb.44.249

Kinetic studies of the photochemical decomposition of alkannin/shikonin enantiomers

Fu An Chen, Hui Wen Cheng, An-Bang Wu, Hsing Chu Hsu, Chau Yang Chen

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The photodegradation of alkannin/shikonin (A/S) was studied as a function of solvent polarity, pH and ionic strength. This process follows an apparent first-order kinetic reaction. The photodegradation rate is inversely proportional to the solvent polarity in the order of chloroform > dichloromethane > 2-propanol > ethanol > methanol. The rate-pH profile reveals that A/S is more stable in an acidic condition: marginally subject to specific acid or base catalysis and is affected by two ionizable groups on the molecule. Ionic strength does not affect the photochemical decomposition rate at pH 5, 9 or 12.

Original language	English
Pages (from-to)	249-251
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	44
Issue number	1
DOIs	https://doi.org/10.1248/cpb.44.249
Publication status	Published - Jan 1996

Keywords

alkannin/shikonin enantiomer
photochemical decomposition
photodegradation
shikon

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.44.249

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abstract = "The photodegradation of alkannin/shikonin (A/S) was studied as a function of solvent polarity, pH and ionic strength. This process follows an apparent first-order kinetic reaction. The photodegradation rate is inversely proportional to the solvent polarity in the order of chloroform > dichloromethane > 2-propanol > ethanol > methanol. The rate-pH profile reveals that A/S is more stable in an acidic condition: marginally subject to specific acid or base catalysis and is affected by two ionizable groups on the molecule. Ionic strength does not affect the photochemical decomposition rate at pH 5, 9 or 12.",

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AU - Chen, Chau Yang

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AB - The photodegradation of alkannin/shikonin (A/S) was studied as a function of solvent polarity, pH and ionic strength. This process follows an apparent first-order kinetic reaction. The photodegradation rate is inversely proportional to the solvent polarity in the order of chloroform > dichloromethane > 2-propanol > ethanol > methanol. The rate-pH profile reveals that A/S is more stable in an acidic condition: marginally subject to specific acid or base catalysis and is affected by two ionizable groups on the molecule. Ionic strength does not affect the photochemical decomposition rate at pH 5, 9 or 12.

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Kinetic studies of the photochemical decomposition of alkannin/shikonin enantiomers

Abstract

Keywords

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