Kawasaki disease: An update on diagnosis and treatment

Ho Chang Kuo, Kuender D. Yang, Wei Chiao Chang, Luo Ping Ger, Kai Sheng Hsieh

Research output: Contribution to journalReview articlepeer-review

113 Citations (Scopus)


Kawasaki disease (KD) is an acute multi-system vasculitis syndrome of unknown etiology occurring mostly in infants and children younger than 5 years of age. In developed countries, it is the leading cause of acquired heart disease in children. However, KD remains a mysterious disease. Some viruses potentially causing the condition have been isolated, but the results have not been able to be reproduced. This article reviews and summarizes different aspects of KD and provides updated information on diagnosis and treatment. The supplementary criteria for incomplete presentation of KD patients suggested by the American Heart Association, treatment (including tumor necrosis factor-alpha antagonist, methylprednisolone pulse therapy, statins, plasma exchange, and cytotoxic agents) for those with intravenous immunoglobulin treatment failure, and other experiences are also included in this review.

Original languageEnglish
Pages (from-to)4-11
Number of pages8
JournalPediatrics and Neonatology
Issue number1
Publication statusPublished - Feb 2012
Externally publishedYes


  • IVIG
  • Kawasaki disease
  • coronary artery lesion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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