Janus-faced bacterial regulation of epithelial cell death and survival: Association with colon carcinogenesis

Wei Ting Kuo; Tsung Chun Lee; Linda Chia Hui Yu

doi:10.1080/23723556.2015.1029064

Janus-faced bacterial regulation of epithelial cell death and survival: Association with colon carcinogenesis

Wei Ting Kuo, Tsung Chun Lee, Linda Chia Hui Yu

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Gut microbiota and lipopolysaccharide (LPS) signaling have been associated with colon cancer development. Our recent findings demonstrated that LPS receptor subunits expressed on colonocytes have antagonistic roles in cell death and tumorigenesis: epithelial toll-like receptor 4 (TLR4) confers resistance to the apoptosis induced by its co-receptor CD14 and contributes to epithelial transition to cancer.

Original language	English
Article number	e1029064
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1029064
Publication status	Published - Jan 2 2016
Externally published	Yes

Keywords

apoptosis
colorectal carcinoma
innate immunity
intestinal homeostasis
lipopolysaccharide

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2015.1029064

Cite this

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title = "Janus-faced bacterial regulation of epithelial cell death and survival: Association with colon carcinogenesis",

abstract = "Gut microbiota and lipopolysaccharide (LPS) signaling have been associated with colon cancer development. Our recent findings demonstrated that LPS receptor subunits expressed on colonocytes have antagonistic roles in cell death and tumorigenesis: epithelial toll-like receptor 4 (TLR4) confers resistance to the apoptosis induced by its co-receptor CD14 and contributes to epithelial transition to cancer.",

keywords = "apoptosis, colorectal carcinoma, innate immunity, intestinal homeostasis, lipopolysaccharide",

author = "Kuo, {Wei Ting} and Lee, {Tsung Chun} and Yu, {Linda Chia Hui}",

note = "Funding Information: This study was supported by funding from the Ministry of Science and Tech nology (MOST 102-2628-B-002-009- MY3) and National Taiwan University (NTU-CDP-104R7798). Publisher Copyright: {\textcopyright} 2016, {\textcopyright} 2016 Taylor & Francis Group, LLC.",

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TY - JOUR

T1 - Janus-faced bacterial regulation of epithelial cell death and survival

T2 - Association with colon carcinogenesis

AU - Kuo, Wei Ting

AU - Lee, Tsung Chun

AU - Yu, Linda Chia Hui

N1 - Funding Information: This study was supported by funding from the Ministry of Science and Tech nology (MOST 102-2628-B-002-009- MY3) and National Taiwan University (NTU-CDP-104R7798). Publisher Copyright: © 2016, © 2016 Taylor & Francis Group, LLC.

PY - 2016/1/2

Y1 - 2016/1/2

N2 - Gut microbiota and lipopolysaccharide (LPS) signaling have been associated with colon cancer development. Our recent findings demonstrated that LPS receptor subunits expressed on colonocytes have antagonistic roles in cell death and tumorigenesis: epithelial toll-like receptor 4 (TLR4) confers resistance to the apoptosis induced by its co-receptor CD14 and contributes to epithelial transition to cancer.

AB - Gut microbiota and lipopolysaccharide (LPS) signaling have been associated with colon cancer development. Our recent findings demonstrated that LPS receptor subunits expressed on colonocytes have antagonistic roles in cell death and tumorigenesis: epithelial toll-like receptor 4 (TLR4) confers resistance to the apoptosis induced by its co-receptor CD14 and contributes to epithelial transition to cancer.

KW - apoptosis

KW - colorectal carcinoma

KW - innate immunity

KW - intestinal homeostasis

KW - lipopolysaccharide

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DO - 10.1080/23723556.2015.1029064

M3 - Article

AN - SCOPUS:85050760572

SN - 2372-3556

VL - 3

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 1

M1 - e1029064

ER -

Janus-faced bacterial regulation of epithelial cell death and survival: Association with colon carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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