Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

Ho-Chang Kuo; Kuender D. Yang; Suh-Hang Hank Juo; Chi-Di Liang; Wei-Chiao Chen; Yu-Shiuan Wang; Chih-Hung Lee; Edward Hsi; Hong-Ren Yu; Peng-Yeong Woon; I-Chun Lin; Chien-Fu Huang; Daw-Yang Hwang; Chiu-Ping Lee; Li-Yan Lin; Wei Pin Chang; Wei-Chiao Chang

doi:10.1371/journal.pone.0017370

Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

Ho-Chang Kuo, Kuender D. Yang, Suh-Hang Hank Juo, Chi-Di Liang, Wei-Chiao Chen, Yu-Shiuan Wang, Chih-Hung Lee, Edward Hsi, Hong-Ren Yu, Peng-Yeong Woon, I-Chun Lin, Chien-Fu Huang, Daw-Yang Hwang, Chiu-Ping Lee, Li-Yan Lin, Wei Pin Chang, Wei-Chiao Chang

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

Original language	English
Article number	e17370
Journal	PLoS ONE
Volume	6
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0017370
Publication status	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1371/journal.pone.0017370

Cite this

Kuo, H.-C., Yang, K. D., Juo, S.-H. H., Liang, C.-D., Chen, W.-C., Wang, Y.-S., Lee, C.-H., Hsi, E., Yu, H.-R., Woon, P.-Y., Lin, I.-C., Huang, C.-F., Hwang, D.-Y., Lee, C.-P., Lin, L.-Y., Chang, W. P., & Chang, W.-C. (2011). Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population. PLoS ONE, 6(4), Article e17370. https://doi.org/10.1371/journal.pone.0017370

@article{25a8efa10f0145238bd2641a60bd6050,

title = "Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population",

abstract = "Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.",

author = "Ho-Chang Kuo and Yang, {Kuender D.} and Juo, {Suh-Hang Hank} and Chi-Di Liang and Wei-Chiao Chen and Yu-Shiuan Wang and Chih-Hung Lee and Edward Hsi and Hong-Ren Yu and Peng-Yeong Woon and I-Chun Lin and Chien-Fu Huang and Daw-Yang Hwang and Chiu-Ping Lee and Li-Yan Lin and Chang, {Wei Pin} and Wei-Chiao Chang",

year = "2011",

doi = "10.1371/journal.pone.0017370",

language = "English",

volume = "6",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "4",

}

TY - JOUR

T1 - Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

AU - Kuo, Ho-Chang

AU - Yang, Kuender D.

AU - Juo, Suh-Hang Hank

AU - Liang, Chi-Di

AU - Chen, Wei-Chiao

AU - Wang, Yu-Shiuan

AU - Lee, Chih-Hung

AU - Hsi, Edward

AU - Yu, Hong-Ren

AU - Woon, Peng-Yeong

AU - Lin, I-Chun

AU - Huang, Chien-Fu

AU - Hwang, Daw-Yang

AU - Lee, Chiu-Ping

AU - Lin, Li-Yan

AU - Chang, Wei Pin

AU - Chang, Wei-Chiao

PY - 2011

Y1 - 2011

N2 - Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

AB - Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

UR - http://www.scopus.com/inward/record.url?scp=79955018203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955018203&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0017370

DO - 10.1371/journal.pone.0017370

M3 - Article

C2 - 21533171

AN - SCOPUS:79955018203

SN - 1932-6203

VL - 6

JO - PLoS ONE

JF - PLoS ONE

IS - 4

M1 - e17370

ER -

Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this