TY - JOUR
T1 - Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin
AU - Gallo, Robert C.
AU - Whang-Peng, Jacqueline
AU - Perry, Seymour
PY - 1969/12/1
Y1 - 1969/12/1
N2 - The plant cytokinin isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of DNA synthesis, transformation, and mitosis of the phytohemagglutinin- stimulated lymphocyte. The stage of the cell cycle and the concentrations used are critical for these effects. The addition of isopentenyladenosine within the first 12 hours after phytohemagglutinin at a concentration above 10-6 molar results in inhibition, while lower concentrations (between 10 -7 and 10-6 molar), added at 24 hours or later, have a stimulatory effect.
AB - The plant cytokinin isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of DNA synthesis, transformation, and mitosis of the phytohemagglutinin- stimulated lymphocyte. The stage of the cell cycle and the concentrations used are critical for these effects. The addition of isopentenyladenosine within the first 12 hours after phytohemagglutinin at a concentration above 10-6 molar results in inhibition, while lower concentrations (between 10 -7 and 10-6 molar), added at 24 hours or later, have a stimulatory effect.
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U2 - 10.1126/science.165.3891.400
DO - 10.1126/science.165.3891.400
M3 - Article
C2 - 5789436
AN - SCOPUS:0014690699
SN - 0036-8075
VL - 165
SP - 400
EP - 402
JO - Science
JF - Science
IS - 3891
ER -