Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp

Kuei Hung Lai, Zheng Hao Huang, Mohamed El-Shazly, Bo Rong Peng, Wen Chi Wei, Jui Hsin Su

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The marine sponge of the genus Geodia, Jaspis, Rhabdastrella, and Stelletta are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (1) and rhabdastin I (2). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds 1 and 2 showed activities against K562 (IC50 11.7 and 9.8 μM) and Molt4 (IC50 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.

Original languageEnglish
Article number206
JournalMarine Drugs
Issue number4
Publication statusPublished - Apr 6 2021


  • anti-leukemia
  • isomalabaricane
  • tetrahydrofuran moiety

ASJC Scopus subject areas

  • Drug Discovery


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