Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp

Kuei Hung Lai; Zheng Hao Huang; Mohamed El-Shazly; Bo Rong Peng; Wen Chi Wei; Jui Hsin Su

doi:10.3390/md19040206

Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp

Kuei Hung Lai, Zheng Hao Huang, Mohamed El-Shazly, Bo Rong Peng, Wen Chi Wei, Jui Hsin Su

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The marine sponge of the genus Geodia, Jaspis, Rhabdastrella, and Stelletta are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (1) and rhabdastin I (2). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds 1 and 2 showed activities against K562 (IC50 11.7 and 9.8 μM) and Molt4 (IC50 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.

Original language	English
Article number	206
Journal	Marine Drugs
Volume	19
Issue number	4
DOIs	https://doi.org/10.3390/md19040206
Publication status	Published - Apr 6 2021

Keywords

anti-leukemia
isomalabaricane
tetrahydrofuran moiety

ASJC Scopus subject areas

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md19040206

Cite this

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title = "Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp",

abstract = "The marine sponge of the genus Geodia, Jaspis, Rhabdastrella, and Stelletta are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (1) and rhabdastin I (2). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds 1 and 2 showed activities against K562 (IC50 11.7 and 9.8 μM) and Molt4 (IC50 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.",

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author = "Lai, {Kuei Hung} and Huang, {Zheng Hao} and Mohamed El-Shazly and Peng, {Bo Rong} and Wei, {Wen Chi} and Su, {Jui Hsin}",

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AU - Huang, Zheng Hao

AU - El-Shazly, Mohamed

AU - Peng, Bo Rong

AU - Wei, Wen Chi

AU - Su, Jui Hsin

PY - 2021/4/6

Y1 - 2021/4/6

N2 - The marine sponge of the genus Geodia, Jaspis, Rhabdastrella, and Stelletta are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (1) and rhabdastin I (2). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds 1 and 2 showed activities against K562 (IC50 11.7 and 9.8 μM) and Molt4 (IC50 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.

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KW - tetrahydrofuran moiety

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Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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