Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin

C. H. Chiu; L. H. Su; C. Chu; J. H. Chia; T. L. Wu; T. Y. Lin; Y. S. Lee; J. T. Ou

doi:10.1016/S0140-6736(04)16003-0

Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin

C. H. Chiu, L. H. Su, C. Chu, J. H. Chia, T. L. Wu, T. Y. Lin, Y. S. Lee, J. T. Ou

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Salmonella enterica serotype choleraesuis (S choleraesuis) usually causes systemic infections in man that need antimicrobial treatment. We isolated a strain of S choleraesuis that was resistant to ceftriaxone and ciprofloxacin from a patient with sepsis. Ciprofloxacin resistance was associated with mutations in gyrA and parC, whereas the ampC gene (bla_CMY-2), responsible for ceftriaxone resistance, was carried by a transposon-like mobile element. This element was found inserted into finQ of a potentially transmissible 140 kb plasmid, with an 8 bp direct repeat flanking the junction regions. The appearance of this resistant S choleraesuis is a serious threat to public health, and thus constant surveillance is warranted.

Original language	English
Pages (from-to)	1285-1286
Number of pages	2
Journal	Lancet
Volume	363
Issue number	9417
DOIs	https://doi.org/10.1016/S0140-6736(04)16003-0
Publication status	Published - Apr 17 2004
Externally published	Yes

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0140-6736(04)16003-0

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title = "Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin",

abstract = "Salmonella enterica serotype choleraesuis (S choleraesuis) usually causes systemic infections in man that need antimicrobial treatment. We isolated a strain of S choleraesuis that was resistant to ceftriaxone and ciprofloxacin from a patient with sepsis. Ciprofloxacin resistance was associated with mutations in gyrA and parC, whereas the ampC gene (blaCMY-2), responsible for ceftriaxone resistance, was carried by a transposon-like mobile element. This element was found inserted into finQ of a potentially transmissible 140 kb plasmid, with an 8 bp direct repeat flanking the junction regions. The appearance of this resistant S choleraesuis is a serious threat to public health, and thus constant surveillance is warranted.",

author = "Chiu, {C. H.} and Su, {L. H.} and C. Chu and Chia, {J. H.} and Wu, {T. L.} and Lin, {T. Y.} and Lee, {Y. S.} and Ou, {J. T.}",

note = "Funding Information: This study was supported by a grant (SMRPD32010) from the Chang Gung Research Fund, Taoyuan, Taiwan. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2004",

month = apr,

day = "17",

doi = "10.1016/S0140-6736(04)16003-0",

language = "English",

volume = "363",

pages = "1285--1286",

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TY - JOUR

T1 - Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin

AU - Chiu, C. H.

AU - Su, L. H.

AU - Chu, C.

AU - Chia, J. H.

AU - Wu, T. L.

AU - Lin, T. Y.

AU - Lee, Y. S.

AU - Ou, J. T.

N1 - Funding Information: This study was supported by a grant (SMRPD32010) from the Chang Gung Research Fund, Taoyuan, Taiwan. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2004/4/17

Y1 - 2004/4/17

N2 - Salmonella enterica serotype choleraesuis (S choleraesuis) usually causes systemic infections in man that need antimicrobial treatment. We isolated a strain of S choleraesuis that was resistant to ceftriaxone and ciprofloxacin from a patient with sepsis. Ciprofloxacin resistance was associated with mutations in gyrA and parC, whereas the ampC gene (blaCMY-2), responsible for ceftriaxone resistance, was carried by a transposon-like mobile element. This element was found inserted into finQ of a potentially transmissible 140 kb plasmid, with an 8 bp direct repeat flanking the junction regions. The appearance of this resistant S choleraesuis is a serious threat to public health, and thus constant surveillance is warranted.

AB - Salmonella enterica serotype choleraesuis (S choleraesuis) usually causes systemic infections in man that need antimicrobial treatment. We isolated a strain of S choleraesuis that was resistant to ceftriaxone and ciprofloxacin from a patient with sepsis. Ciprofloxacin resistance was associated with mutations in gyrA and parC, whereas the ampC gene (blaCMY-2), responsible for ceftriaxone resistance, was carried by a transposon-like mobile element. This element was found inserted into finQ of a potentially transmissible 140 kb plasmid, with an 8 bp direct repeat flanking the junction regions. The appearance of this resistant S choleraesuis is a serious threat to public health, and thus constant surveillance is warranted.

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DO - 10.1016/S0140-6736(04)16003-0

M3 - Article

C2 - 15094275

AN - SCOPUS:1942439102

SN - 0140-6736

VL - 363

SP - 1285

EP - 1286

JO - Lancet

JF - Lancet

IS - 9417

ER -

Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin

Abstract

ASJC Scopus subject areas

UN SDGs

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