Is fibromyalgia a distinct clinical syndrome?

C. L. Rau, I. J. Russell

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


The validity of the fibromyalgia syndrome (FMS) as a distinct clinical entity has been challenged for several reasons. Many skeptics express concern about the subjective nature of chronic pain, the subjectivity of the tender point (TeP) examination, the lack of a gold standard laboratory test, and the absence of a clear pathogenic mechanism by which to define FMS. Another expressed concern has been the relative nature of the pain-distress relationship in the rheumatology clinic. The apparently continuous relationship between TePs and somatic distress across a variety of clinical disorders is said to argue against FMS as a separate clinical disorder. The most aggressive challenges of the FMS concept have been from legal defenses of insurance carriers motivated by economic concerns. Other forms of critique have presented as psychiatric dogma, uninformed posturing, suspicion of malingering, ignorance of nociceptive physiology, and occasionally have resulted from honest misunderstanding. It is not likely that a few paragraphs of data and logic will cause an unbeliever to change an ingrained opinion. Therefore, this review describes the clinical manifestations of FMS, responds to some of the theoretic arguments against it, and discusses some possible pathophysiologic mechanisms by which FMS may develop and persist as a unique syndrome.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalCurrent review of pain
Issue number4
Publication statusPublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Insect Science


Dive into the research topics of 'Is fibromyalgia a distinct clinical syndrome?'. Together they form a unique fingerprint.

Cite this