Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience

Shu Huey Chen; Chi Jui Lu; Shu Hui Wen; Ya Jun Zheng; Shang Hsien Yang; Yu Chieh Su; Dian Kun Li

doi:10.1016/j.transci.2009.01.014

Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience

Shu Huey Chen, Chi Jui Lu, Shu Hui Wen, Ya Jun Zheng, Shang Hsien Yang, Yu Chieh Su, Dian Kun Li

Research output: Contribution to journal › Article › peer-review

Abstract

Successful allogeneic PBSC transplantation depends upon the infusion of an adequate number of CD34+ cells to patients. Granulocyte-colony-stimulating factors (G-CSF) mobilized PBSC were harvested on 5th day after stimulation from donors. When the CD34+ cell target yield was not achieved; secondary apheresis was performed the following day. Before September 2006, 67 donors (Group A) received five doses of G-CSF. After September 2006, a sixth dose of G-CSF was administered to 35 donors (Group B) to improve CD34+ yield. The mean CD34+-cell concentration of the second PBSC harvest was significantly higher in Group B (1,087 × 10⁶/l vs. 767 × 10⁶/l; P = 0.031).

Original language	English
Pages (from-to)	87-90
Number of pages	4
Journal	Transfusion and Apheresis Science
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/j.transci.2009.01.014
Publication status	Published - Apr 2009
Externally published	Yes

ASJC Scopus subject areas

Hematology

Access to Document

10.1016/j.transci.2009.01.014

Cite this

@article{0d20b2b3697f4ea89e4fdbe7f632b1f8,

title = "Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience",

abstract = "Successful allogeneic PBSC transplantation depends upon the infusion of an adequate number of CD34+ cells to patients. Granulocyte-colony-stimulating factors (G-CSF) mobilized PBSC were harvested on 5th day after stimulation from donors. When the CD34+ cell target yield was not achieved; secondary apheresis was performed the following day. Before September 2006, 67 donors (Group A) received five doses of G-CSF. After September 2006, a sixth dose of G-CSF was administered to 35 donors (Group B) to improve CD34+ yield. The mean CD34+-cell concentration of the second PBSC harvest was significantly higher in Group B (1,087 × 106/l vs. 767 × 106/l; P = 0.031).",

author = "Chen, \{Shu Huey\} and Lu, \{Chi Jui\} and Wen, \{Shu Hui\} and Zheng, \{Ya Jun\} and Yang, \{Shang Hsien\} and Su, \{Yu Chieh\} and Li, \{Dian Kun\}",

year = "2009",

month = apr,

doi = "10.1016/j.transci.2009.01.014",

language = "English",

volume = "40",

pages = "87--90",

journal = "Transfusion and Apheresis Science",

issn = "1473-0502",

publisher = "Elsevier Ltd",

number = "2",

}

TY - JOUR

T1 - Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience

AU - Chen, Shu Huey

AU - Lu, Chi Jui

AU - Wen, Shu Hui

AU - Zheng, Ya Jun

AU - Yang, Shang Hsien

AU - Su, Yu Chieh

AU - Li, Dian Kun

PY - 2009/4

Y1 - 2009/4

N2 - Successful allogeneic PBSC transplantation depends upon the infusion of an adequate number of CD34+ cells to patients. Granulocyte-colony-stimulating factors (G-CSF) mobilized PBSC were harvested on 5th day after stimulation from donors. When the CD34+ cell target yield was not achieved; secondary apheresis was performed the following day. Before September 2006, 67 donors (Group A) received five doses of G-CSF. After September 2006, a sixth dose of G-CSF was administered to 35 donors (Group B) to improve CD34+ yield. The mean CD34+-cell concentration of the second PBSC harvest was significantly higher in Group B (1,087 × 106/l vs. 767 × 106/l; P = 0.031).

AB - Successful allogeneic PBSC transplantation depends upon the infusion of an adequate number of CD34+ cells to patients. Granulocyte-colony-stimulating factors (G-CSF) mobilized PBSC were harvested on 5th day after stimulation from donors. When the CD34+ cell target yield was not achieved; secondary apheresis was performed the following day. Before September 2006, 67 donors (Group A) received five doses of G-CSF. After September 2006, a sixth dose of G-CSF was administered to 35 donors (Group B) to improve CD34+ yield. The mean CD34+-cell concentration of the second PBSC harvest was significantly higher in Group B (1,087 × 106/l vs. 767 × 106/l; P = 0.031).

UR - https://www.scopus.com/pages/publications/62949132083

UR - https://www.scopus.com/inward/citedby.url?scp=62949132083&partnerID=8YFLogxK

U2 - 10.1016/j.transci.2009.01.014

DO - 10.1016/j.transci.2009.01.014

M3 - Article

C2 - 19233726

AN - SCOPUS:62949132083

SN - 1473-0502

VL - 40

SP - 87

EP - 90

JO - Transfusion and Apheresis Science

JF - Transfusion and Apheresis Science

IS - 2

ER -

Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this