Involvement of microrna in solid cancer: Role and regulatory mechanisms

Ying Chin Lin; Tso Hsiao Chen; Yu Min Huang; Po Li Wei; Jung Chun Lin

doi:10.3390/biomedicines9040343

Involvement of microrna in solid cancer: Role and regulatory mechanisms

Research output: Contribution to journal › Review article › peer-review

Abstract

MicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal mechanism involved in initiation or progression of human malignancy. Cancer-relevant miRNA is potentially considered the therapeutic target or biomarker toward the precise treatment of cancer. Nevertheless, the regulatory mechanism underlying the altered expression of miRNA in cancer is largely uncovered. Detailed knowledge regarding the influence of miRNAs on solid cancer is critical for exploring its potential of clinical application. Herein, we elucidate the regulatory mechanism regarding how miRNA expression is manipulated and its impact on the pathogenesis of distinct solid cancer.

Original language	English
Article number	343
Journal	Biomedicines
Volume	9
Issue number	4
DOIs	https://doi.org/10.3390/biomedicines9040343
Publication status	Published - Apr 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

MicroRNA
Post-transcriptional regulation
Solid cancer

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry,Genetics and Molecular Biology

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10.3390/biomedicines9040343

Cite this

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title = "Involvement of microrna in solid cancer: Role and regulatory mechanisms",

abstract = "MicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal mechanism involved in initiation or progression of human malignancy. Cancer-relevant miRNA is potentially considered the therapeutic target or biomarker toward the precise treatment of cancer. Nevertheless, the regulatory mechanism underlying the altered expression of miRNA in cancer is largely uncovered. Detailed knowledge regarding the influence of miRNAs on solid cancer is critical for exploring its potential of clinical application. Herein, we elucidate the regulatory mechanism regarding how miRNA expression is manipulated and its impact on the pathogenesis of distinct solid cancer.",

keywords = "MicroRNA, Post-transcriptional regulation, Solid cancer",

author = "Lin, \{Ying Chin\} and Chen, \{Tso Hsiao\} and Huang, \{Yu Min\} and Wei, \{Po Li\} and Lin, \{Jung Chun\}",

note = "Funding Information: This work was supported by a grant (MOST 109-2622-B-038-002-CC3) from the Ministry of Science and Technology, Taiwan. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = apr,

doi = "10.3390/biomedicines9040343",

language = "English",

volume = "9",

journal = "Biomedicines",

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T1 - Involvement of microrna in solid cancer

T2 - Role and regulatory mechanisms

AU - Lin, Ying Chin

AU - Chen, Tso Hsiao

AU - Huang, Yu Min

AU - Wei, Po Li

AU - Lin, Jung Chun

N1 - Funding Information: This work was supported by a grant (MOST 109-2622-B-038-002-CC3) from the Ministry of Science and Technology, Taiwan. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/4

Y1 - 2021/4

N2 - MicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal mechanism involved in initiation or progression of human malignancy. Cancer-relevant miRNA is potentially considered the therapeutic target or biomarker toward the precise treatment of cancer. Nevertheless, the regulatory mechanism underlying the altered expression of miRNA in cancer is largely uncovered. Detailed knowledge regarding the influence of miRNAs on solid cancer is critical for exploring its potential of clinical application. Herein, we elucidate the regulatory mechanism regarding how miRNA expression is manipulated and its impact on the pathogenesis of distinct solid cancer.

AB - MicroRNAs (miRNAs) function as the post-transcriptional factor that finetunes the gene expression by targeting to the specific candidate. Mis-regulated expression of miRNAs consequently disturbs gene expression profile, which serves as the pivotal mechanism involved in initiation or progression of human malignancy. Cancer-relevant miRNA is potentially considered the therapeutic target or biomarker toward the precise treatment of cancer. Nevertheless, the regulatory mechanism underlying the altered expression of miRNA in cancer is largely uncovered. Detailed knowledge regarding the influence of miRNAs on solid cancer is critical for exploring its potential of clinical application. Herein, we elucidate the regulatory mechanism regarding how miRNA expression is manipulated and its impact on the pathogenesis of distinct solid cancer.

KW - MicroRNA

KW - Post-transcriptional regulation

KW - Solid cancer

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UR - https://www.scopus.com/pages/publications/85104022494#tab=citedBy

U2 - 10.3390/biomedicines9040343

DO - 10.3390/biomedicines9040343

M3 - Review article

AN - SCOPUS:85104022494

SN - 2227-9059

VL - 9

JO - Biomedicines

JF - Biomedicines

IS - 4

M1 - 343

ER -

Involvement of microrna in solid cancer: Role and regulatory mechanisms

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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