Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUVmax of FDG-PET scan in esophageal squamous cell carcinoma

Chen Sung Lin; Yu Yi Huang; Siao Cian Pan; Chih Tao Cheng; Chia Chuan Liu; Chih Hsun Shih; Hsiang Ling Ho; Yi Chen Yeh; Teh Ying Chou; Ming Yuan Lee; Yau Huei Wei

doi:10.1016/j.mito.2019.05.001

Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUV_max of FDG-PET scan in esophageal squamous cell carcinoma

Chen Sung Lin, Yu Yi Huang, Siao Cian Pan, Chih Tao Cheng, Chia Chuan Liu, Chih Hsun Shih, Hsiang Ling Ho, Yi Chen Yeh, Teh Ying Chou, Ming Yuan Lee, Yau Huei Wei

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUV_max) of ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNA^ESCC copy number (p < .05) but higher SUV_max-ESCC (p < .05), respectively. Lower mtDNA^ESCC copy number correlated with higher SUV_max-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNA^ESCC copy number (p = .056) but higher SUV_max-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.

Original language	English
Pages (from-to)	54-63
Number of pages	10
Journal	Mitochondrion
Volume	47
DOIs	https://doi.org/10.1016/j.mito.2019.05.001
Publication status	Published - Jul 2019
Externally published	Yes

Keywords

F-fluorodeoxyglucose positron emission tomography (FDG-PET)
Esophageal squamous cell carcinoma (ESCC)
Maximum standard uptake value (SUV)
Mitochondrial DNA (mtDNA) copy number
p53
Warburg effect

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

Access to Document

10.1016/j.mito.2019.05.001

Cite this

Lin, C. S., Huang, Y. Y., Pan, S. C., Cheng, C. T., Liu, C. C., Shih, C. H., Ho, H. L., Yeh, Y. C., Chou, T. Y., Lee, M. Y., & Wei, Y. H. (2019). Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUV_max of FDG-PET scan in esophageal squamous cell carcinoma. Mitochondrion, 47, 54-63. https://doi.org/10.1016/j.mito.2019.05.001

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title = "Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUVmax of FDG-PET scan in esophageal squamous cell carcinoma",

abstract = "We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNAESCC copy number (p < .05) but higher SUVmax-ESCC (p < .05), respectively. Lower mtDNAESCC copy number correlated with higher SUVmax-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNAESCC copy number (p = .056) but higher SUVmax-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.",

keywords = "F-fluorodeoxyglucose positron emission tomography (FDG-PET), Esophageal squamous cell carcinoma (ESCC), Maximum standard uptake value (SUV), Mitochondrial DNA (mtDNA) copy number, p53, Warburg effect",

author = "Lin, {Chen Sung} and Huang, {Yu Yi} and Pan, {Siao Cian} and Cheng, {Chih Tao} and Liu, {Chia Chuan} and Shih, {Chih Hsun} and Ho, {Hsiang Ling} and Yeh, {Yi Chen} and Chou, {Teh Ying} and Lee, {Ming Yuan} and Wei, {Yau Huei}",

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year = "2019",

month = jul,

doi = "10.1016/j.mito.2019.05.001",

language = "English",

volume = "47",

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AU - Lin, Chen Sung

AU - Huang, Yu Yi

AU - Pan, Siao Cian

AU - Cheng, Chih Tao

AU - Liu, Chia Chuan

AU - Shih, Chih Hsun

AU - Ho, Hsiang Ling

AU - Yeh, Yi Chen

AU - Chou, Teh Ying

AU - Lee, Ming Yuan

AU - Wei, Yau Huei

PY - 2019/7

Y1 - 2019/7

N2 - We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNAESCC copy number (p < .05) but higher SUVmax-ESCC (p < .05), respectively. Lower mtDNAESCC copy number correlated with higher SUVmax-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNAESCC copy number (p = .056) but higher SUVmax-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.

AB - We appraised Warburg effect through analysis of mitochondrial DNA (mtDNA) copy number and maximum standard uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan and their alterations in esophageal squamous cell carcinoma (ESCC). Later T-status and longer longitudinal tumor length were associated with lower mtDNAESCC copy number (p < .05) but higher SUVmax-ESCC (p < .05), respectively. Lower mtDNAESCC copy number correlated with higher SUVmax-ESCC, reciprocally (p < .05). ESCCs expressing mutant p53 protein had lower mtDNAESCC copy number (p = .056) but higher SUVmax-ESCC (p = .046). We conclude that mutant p53 protein may be involved in the Warburg effect of ESCC.

KW - F-fluorodeoxyglucose positron emission tomography (FDG-PET)

KW - Esophageal squamous cell carcinoma (ESCC)

KW - Maximum standard uptake value (SUV)

KW - Mitochondrial DNA (mtDNA) copy number

KW - p53

KW - Warburg effect

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