Investigation of bone growth in additive-manufactured pedicle screw implant by using Ti-6Al-4V and bioactive glass powder composite

Tu Ngoc Lam, Minh Giam Trinh, Chih Chieh Huang, Pei Ching Kung, Wei Chin Huang, Wei Chang, Lia Amalia, Hsu Hsuan Chin, Nien Ti Tsou, Shao Ju Shih, San Yuan Chen, Chun Chieh Wang, Pei I. Tsai, Meng Huang Wu, E. Wen Huang

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


In this study, we optimized the geometry and composition of additive-manufactured pedicle screws. Metal powders of titanium-aluminum-vanadium (Ti-6Al-4V) were mixed with reactive glass-ceramic biomaterials of bioactive glass (BG) powders. To optimize the geometry of pedicle screws, we applied a novel numerical approach to proposing the optimal shape of the healing chamber to promote biological healing. We examined the geometry and composition effects of pedicle screw implants on the interfacial autologous bone attachment and bone graft incorporation through in vivo studies. The addition of an optimal amount of BG to Ti-6Al-4V leads to a lower elastic modulus of the ceramic-metal composite material, effectively reducing the stress-shielding effects. Pedicle screw implants with optimal shape design and made of the composite material of Ti-6Al-4V doped with BG fabricated through additive manufacturing exhibit greater osseointegration and a more rapid bone volume fraction during the fracture healing process 120 days after implantation, per in vivo studies.

Original languageEnglish
Article number7438
Pages (from-to)1-13
Number of pages13
JournalInternational journal of molecular sciences
Issue number20
Publication statusPublished - Oct 2020


  • Additive manufacturing
  • Bioactive glass
  • Osseointegration
  • Pedicle screw implant
  • Stress-shielding effect
  • X-ray tomography

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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