Investigation of antiulcer activities of imidazo[1,2-α]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles with electron-topological (ET) method

The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.