Invasive pulmonary aspergillosis with cerebral abscess in a patient with idiopathic thrombocytopenic purpura

Hung Chin Tsai, Susan Shin Jung Lee, Shue Ren Wann, Yao Shen Chen, Jyh Seng Wang, Yung Ching Liu

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5 Citations (Scopus)


Invasive aspergillosis is a devastating infection in immunocompromised hosts. The lung is the most common site of primary infection, and the central nervous system is the most common secondary site of invasive disease. Invasive aspergillosis in autoimmunopathies treated with corticosteroids has rarely been reported in the literature. Herein, we report the case of a 48-year-old female patient with idiopathic thrombocytopenic purpura complicated with fatal invasive pulmonary and cerebral aspergillosis. She had been given 1,016 g intravenous amphotericin B empirically for lung infection during a previous admission. At presentation, she had fever, cough, and shortness of breath for 4 weeks. Chest radiography revealed a huge cavity over the left upper lung field. Bronchoscopic biopsy and culture showed Aspergillus species. She was initially treated with intravenous amphotericin B (0.9 mg/kg/day), and intravenous hydrocortisone for her idiopathic thrombocytopenic purpura. However, deterioration of consciousness occurred 12 days after hospitalization. Computed tomography of the brain showed ring-like cystic mass lesions in the right side basal ganglion. Stereotactic aspiration of the brain revealed Aspergillus species. Her condition exacerbated despite combination treatment with high-dose amphotericin B (1.2 mg/kg/day) and itraconazole (400 mg/day). She died 24 days after admission. This case suggests that treatment with corticosteroids and premature discontinuation of antifungal drugs bear the risk of fatal cerebral involvement in patients with invasive pulmonary aspergillosis.

Original languageEnglish
Pages (from-to)278-281
Number of pages4
JournalJournal of the Chinese Medical Association
Issue number6
Publication statusPublished - Jun 2006
Externally publishedYes


  • Brain abscess
  • Idiopathic thrombocytopenic purpura
  • Invasive pulmonary aspergillosis

ASJC Scopus subject areas

  • General Medicine


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