TY - GEN
T1 - Invasive PLA microneedle fabrication applied to drug delivery system
AU - Kuo, Hsin Chuan
AU - Lin, Yi
AU - Shen, Yung Kang
AU - Kang, Sheng Chieh
PY - 2011
Y1 - 2011
N2 - This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.
AB - This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.
KW - Micro hot embossing
KW - Numerical simulation
KW - PLA microneedle
KW - Taguchi method
KW - Transepidermal water loss (TEWL)
UR - http://www.scopus.com/inward/record.url?scp=80054806075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054806075&partnerID=8YFLogxK
U2 - 10.1109/MACE.2011.5988769
DO - 10.1109/MACE.2011.5988769
M3 - Conference contribution
AN - SCOPUS:80054806075
SN - 9781424494392
T3 - 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings
SP - 7437
EP - 7440
BT - 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings
T2 - 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011
Y2 - 15 July 2011 through 17 July 2011
ER -