Invasive PLA microneedle fabrication applied to drug delivery system

Hsin Chuan Kuo; Yi Lin; Yung Kang Shen; Sheng Chieh Kang

doi:10.1109/MACE.2011.5988769

Invasive PLA microneedle fabrication applied to drug delivery system

Hsin Chuan Kuo, Yi Lin, Yung Kang Shen, Sheng Chieh Kang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Citations (Scopus)

Abstract

This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.

Original language	English
Title of host publication	2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings
Pages	7437-7440
Number of pages	4
DOIs	https://doi.org/10.1109/MACE.2011.5988769
Publication status	Published - 2011
Event	2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Inner Mongolia, China Duration: Jul 15 2011 → Jul 17 2011

Other

Other	2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011
Country/Territory	China
City	Inner Mongolia
Period	7/15/11 → 7/17/11

Keywords

Micro hot embossing
Numerical simulation
PLA microneedle
Taguchi method
Transepidermal water loss (TEWL)

ASJC Scopus subject areas

Control and Systems Engineering
Mechanical Engineering

Access to Document

10.1109/MACE.2011.5988769

Cite this

Kuo, HC, Lin, Y, Shen, YK & Kang, SC 2011, Invasive PLA microneedle fabrication applied to drug delivery system. in 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings., 5988769, pp. 7437-7440, 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011, Inner Mongolia, China, 7/15/11. https://doi.org/10.1109/MACE.2011.5988769

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title = "Invasive PLA microneedle fabrication applied to drug delivery system",

abstract = "This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.",

keywords = "Micro hot embossing, Numerical simulation, PLA microneedle, Taguchi method, Transepidermal water loss (TEWL)",

author = "Kuo, {Hsin Chuan} and Yi Lin and Shen, {Yung Kang} and Kang, {Sheng Chieh}",

year = "2011",

doi = "10.1109/MACE.2011.5988769",

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T1 - Invasive PLA microneedle fabrication applied to drug delivery system

AU - Kuo, Hsin Chuan

AU - Lin, Yi

AU - Shen, Yung Kang

AU - Kang, Sheng Chieh

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N2 - This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.

AB - This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.

KW - Micro hot embossing

KW - Numerical simulation

KW - PLA microneedle

KW - Taguchi method

KW - Transepidermal water loss (TEWL)

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Invasive PLA microneedle fabrication applied to drug delivery system

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Keywords

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