Invasive infections due to vancomycin-resistant enterococci in adult patients

Shio Shin Jean, Chi Tai Fang, Hua Kung Wang, Po Ren Hsueh, Shan Chwen Chang, Kwen Tay Luh

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Since 1990, vancomycin-resistant enterococci have emerged as important nosocomial pathogens. Invasive infections caused by these organisms have challenged most physicians because they are resistant to multiple antibiotics. We analyzed the clinical characteristics of adult patients with invasive vancomycin- resistant enterococci infections in the National Taiwan University Hospital from January 1993 through December 2000. A total of 11 adult patients were identified, 9 of whom had bacteremia (7 caused by vancomycin-resistant Enterococcus faecalis and 2 by vancomycin-resistant Enterococcus faecium) and one each had thoracic empyema (vancomycin-resistant E. faecium) and peritonitis (vancomycin-resistant E. faecium). Five patients had rectal swab cultures positive for vancomycin-resistant enterococci; 4 of them had underlying malignancies. The majority (91%) of these patients had prolonged hospitalization and prior long-term use of broad-spectrum cephalosporins (ceftriaxone, ceftazidime, or cefepime) or anti-anaerobic agents (clindamycin or metronidazole). The crude mortality rate was 64%. In conclusion, invasive infection caused by vancomycin-resistant enterococci is an emerging problem among hospitalized patients in Taiwan, particularly those with severe underlying diseases and exposure to multiple antibiotics.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Issue number4
Publication statusPublished - 2001
Externally publishedYes


  • Invasive infection
  • Vancomycin-resistant enterococci

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Immunology and Allergy


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