Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics

Chia Hung Lee; Shih Hsun Cheng; I. Ping Huang; Jeffrey S. Souris; Chung Shi Yang; Chung Yuan Mou; Leu Wei Lo

doi:10.1002/anie.201002639

Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics

Chia Hung Lee, Shih Hsun Cheng, I. Ping Huang, Jeffrey S. Souris, Chung Shi Yang, Chung Yuan Mou, Leu Wei Lo

Research output: Contribution to journal › Article › peer-review

315 Citations (Scopus)

Abstract

Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.

Original language	English
Pages (from-to)	8214-8219
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	44
DOIs	https://doi.org/10.1002/anie.201002639
Publication status	Published - Oct 25 2010
Externally published	Yes

Keywords

Antitumor agents
Apoptosis
Controlled release
Doxorubicin
Mesoporous silica

ASJC Scopus subject areas

Catalysis
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201002639

Cite this

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title = "Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics",

abstract = "Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.",

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AU - Lee, Chia Hung

AU - Cheng, Shih Hsun

AU - Huang, I. Ping

AU - Souris, Jeffrey S.

AU - Yang, Chung Shi

AU - Mou, Chung Yuan

AU - Lo, Leu Wei

PY - 2010/10/25

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AB - Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.

KW - Antitumor agents

KW - Apoptosis

KW - Controlled release

KW - Doxorubicin

KW - Mesoporous silica

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ER -

Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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