Interleukin-11/gp130 upregulates MMP-13 expression and cell migration in OSCC by activating PI3K/Akt and AP-1 signaling

Chia Yu Wu, Ju Fang Liu, Hsiao Chi Tsai, Huey En Tzeng, Tsung Han Hsieh, Ming Wang, Yu Feng Lin, Chien Chi Lu, Ming Yu Lien, Chih Hsin Tang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Oral squamous cell carcinoma (OSCC) is an extremely common head and neck cancer with a poor 5-year survival rate, especially in cases of metastatic disease. Interleukin (IL)-11 reportedly promotes cell growth and the epithelial–mesenchymal transition process in metastasis. However, the molecular mechanisms of IL-11 in OSCC metastasis are unclear. This study found that IL-11 upregulates matrix metalloproteinase 13 (MMP-13) expression in OSCC via the IL-11 receptor alpha subunit/glycoprotein 130 receptors that activate phosphatidyl-inositol 3-kinase, Ak strain transforming, and activator protein 1 signaling, which subsequently enhance MMP-13-induced tumor metastasis. TIMER2.0 analysis revealed a positive correlation between MMP-13 and IL-11 levels (r = 0.454). Moreover, a strong positive association was observed between higher levels of IL-11 expression in OSCC tissue (p < 0.01), lymph node metastasis (p = 0.0154), and clinical disease stage (p = 0.0337). IL-11 knockdown suppressed the migration of OSCC cells (p < 0.05). The evidence indicates that IL-11 can serve as a new molecular therapeutic target in OSCC metastasis.

Original languageEnglish
Pages (from-to)4551-4562
Number of pages12
JournalJournal of Cellular Physiology
Issue number12
Publication statusPublished - Dec 2022


  • gp130
  • IL-1
  • metastasis
  • MMP-13
  • oral squamous cell carcinoma

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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