Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells

Po Wei Tsai; Lemmuel L. Tayo; Jasmine U. Ting; Cheng Yang Hsieh; Chia Jung Lee; Chih Ling Chen; Hsiao Chuan Yang; Hsing Yu Tsai; Chung Chuan Hsueh; Bor Yann Chen

doi:10.1016/j.indcrop.2022.115944

Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells

Po Wei Tsai, Lemmuel L. Tayo, Jasmine U. Ting, Cheng Yang Hsieh, Chia Jung Lee, Chih Ling Chen, Hsiao Chuan Yang, Hsing Yu Tsai, Chung Chuan Hsueh, Bor Yann Chen

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (−6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.

Original language	English
Article number	115944
Journal	Industrial Crops and Products
Volume	191
DOIs	https://doi.org/10.1016/j.indcrop.2022.115944
Publication status	Published - Jan 2023

Keywords

Biorefinery
Chlorogenic acid
Coffea arabica leaves
COVID-19
Microbial fuel cells
RdRp

ASJC Scopus subject areas

Agronomy and Crop Science

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10.1016/j.indcrop.2022.115944

Cite this

Tsai, P. W., Tayo, L. L., Ting, J. U., Hsieh, C. Y., Lee, C. J., Chen, C. L., Yang, H. C., Tsai, H. Y., Hsueh, C. C., & Chen, B. Y. (2023). Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells. Industrial Crops and Products, 191, Article 115944. https://doi.org/10.1016/j.indcrop.2022.115944

Tsai, PW, Tayo, LL, Ting, JU, Hsieh, CY, Lee, CJ, Chen, CL, Yang, HC, Tsai, HY, Hsueh, CC & Chen, BY 2023, 'Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells', Industrial Crops and Products, vol. 191, 115944. https://doi.org/10.1016/j.indcrop.2022.115944

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title = "Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells",

abstract = "Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (−6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.",

keywords = "Biorefinery, Chlorogenic acid, Coffea arabica leaves, COVID-19, Microbial fuel cells, RdRp",

author = "Tsai, {Po Wei} and Tayo, {Lemmuel L.} and Ting, {Jasmine U.} and Hsieh, {Cheng Yang} and Lee, {Chia Jung} and Chen, {Chih Ling} and Yang, {Hsiao Chuan} and Tsai, {Hsing Yu} and Hsueh, {Chung Chuan} and Chen, {Bor Yann}",

note = "Funding Information: The authors sincerely appreciate financial supports ( MOST 109-2221-E-197-016-MY3 , 110-2221-E-197-008 ) from the Taiwan{\textquoteright}s Ministry of Science and Technology and 108-109 TEEP＠AsiaPlus Program from Taiwan's Ministry of Education . Authors are very thankful to Office of Research and Development, Chang Jung Christian University, for funding this study. Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

month = jan,

doi = "10.1016/j.indcrop.2022.115944",

language = "English",

volume = "191",

journal = "Industrial Crops and Products",

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T1 - Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells

AU - Tsai, Po Wei

AU - Tayo, Lemmuel L.

AU - Ting, Jasmine U.

AU - Hsieh, Cheng Yang

AU - Lee, Chia Jung

AU - Chen, Chih Ling

AU - Yang, Hsiao Chuan

AU - Tsai, Hsing Yu

AU - Hsueh, Chung Chuan

AU - Chen, Bor Yann

N1 - Funding Information: The authors sincerely appreciate financial supports ( MOST 109-2221-E-197-016-MY3 , 110-2221-E-197-008 ) from the Taiwan’s Ministry of Science and Technology and 108-109 TEEP＠AsiaPlus Program from Taiwan's Ministry of Education . Authors are very thankful to Office of Research and Development, Chang Jung Christian University, for funding this study. Publisher Copyright: © 2022 Elsevier B.V.

PY - 2023/1

Y1 - 2023/1

N2 - Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (−6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.

AB - Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (−6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.

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KW - Chlorogenic acid

KW - Coffea arabica leaves

KW - COVID-19

KW - Microbial fuel cells

KW - RdRp

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Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells

Abstract

Keywords

ASJC Scopus subject areas

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