Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan

S. Y. Liu; J. Y. Lin; C. Chu; L. H. Su; T. Y. Lin; C. H. Chiu

doi:10.1016/j.ijantimicag.2005.09.010

Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan

S. Y. Liu, J. Y. Lin, C. Chu, L. H. Su, T. Y. Lin, C. H. Chiu

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the bla_IMP-1 gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no bla_IMP, bla_VIM or bla _CFI genes, indicating that other uncharacterised metallo-β- lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of lateral gene transfer and clonal spread of multiple resistant clones. Strict measures should be implemented to control the further spread of resistance.

Original language	English
Pages (from-to)	81-84
Number of pages	4
Journal	International Journal of Antimicrobial Agents
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.ijantimicag.2005.09.010
Publication status	Published - Jan 2006
Externally published	Yes

Keywords

Acinetobacter baumannii
Imipenem resistance
Integron

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Microbiology
Parasitology
Virology
Immunology and Allergy
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijantimicag.2005.09.010

Cite this

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title = "Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan",

abstract = "We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the blaIMP-1 gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no blaIMP, blaVIM or bla CFI genes, indicating that other uncharacterised metallo-β- lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of lateral gene transfer and clonal spread of multiple resistant clones. Strict measures should be implemented to control the further spread of resistance.",

keywords = "Acinetobacter baumannii, Imipenem resistance, Integron",

author = "Liu, {S. Y.} and Lin, {J. Y.} and C. Chu and Su, {L. H.} and Lin, {T. Y.} and Chiu, {C. H.}",

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AU - Liu, S. Y.

AU - Lin, J. Y.

AU - Chu, C.

AU - Su, L. H.

AU - Lin, T. Y.

AU - Chiu, C. H.

PY - 2006/1

Y1 - 2006/1

N2 - We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the blaIMP-1 gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no blaIMP, blaVIM or bla CFI genes, indicating that other uncharacterised metallo-β- lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of lateral gene transfer and clonal spread of multiple resistant clones. Strict measures should be implemented to control the further spread of resistance.

AB - We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the blaIMP-1 gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no blaIMP, blaVIM or bla CFI genes, indicating that other uncharacterised metallo-β- lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of lateral gene transfer and clonal spread of multiple resistant clones. Strict measures should be implemented to control the further spread of resistance.

KW - Acinetobacter baumannii

KW - Imipenem resistance

KW - Integron

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Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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