@article{b36f5ae839844eca976997aa8c5e909c,
title = "Integrins and Actions of Androgen in Breast Cancer",
abstract = "Androgen has been shown to regulate male physiological activities and cancer proliferation. It is used to antagonize estrogen-induced proliferative effects in breast cancer cells. However, evidence indicates that androgen can stimulate cancer cell growth in estrogen receptor (ER)-positive and ER-negative breast cancer cells via different types of receptors and different mechanisms. Androgen-induced cancer growth and metastasis link with different types of integrins. Integrin αvβ3 is predominantly expressed and activated in cancer cells and rapidly dividing endothelial cells. Programmed death-ligand 1 (PD-L1) also plays a vital role in cancer growth. The part of integrins in action with androgen in cancer cells is not fully mechanically understood. To clarify the interactions between androgen and integrin αvβ3, we carried out molecular modeling to explain the potential interactions of androgen with integrin αvβ3. The androgen-regulated mechanisms on PD-L1 and its effects were also addressed.",
keywords = "androgen, androgen receptor, breast cancer, integrin αvβ3, PD-L",
author = "Tsai, {Chung Che} and Yang, {Yu Chen S.H.} and Chen, {Yi Fong} and Huang, {Lin Yi} and Yang, {Yung Ning} and Lee, {Sheng Yang} and Wang, {Wen Long} and Lee, {Hsin Lun} and Jacqueline Whang-Peng and Lin, {Hung Yun} and Kuan Wang",
note = "Funding Information: This work was supported in part by intra-institutional grants from E-Da Medical Center, Taiwan (EDAHP112024 and EDPJ111068 to Y.-N.Y.), by a 33-research grant from E-Da Medical Center, Taiwan (EDAHS112025 to Y.-N.Y., and EDAHS112031 to L.-Y.H.), by the Chair Professor Research Fund to J.W.-P. and K. Wang, by the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan (DP2-107-20000), by a grant from the Ministry of Science and Technology, Taiwan (NSTC112-2811-B-038-005 to C.-C.T.; MOST109-2314-B-038-038 to Y.-C.S.H.Y.; MOST110-2314-B-038-147 and MOST111-2314-B-038-123 to H.-Y.L.), and by an integrated grant from the Ministry of Science and Technology, Taiwan (NSTC111-2314-B-038-014 to J.W.-P., NSTC111-2314-B-038-015 to H.-Y.L. and NSTC111-2314-B-038-016 to K. Wang). Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
month = sep,
doi = "10.3390/cells12172126",
language = "English",
volume = "12",
journal = "Cells",
issn = "2073-4409",
number = "17",
}
