Integrated anti-hyperlipidemic bioactivity of whole: Citrus grandis [L.] osbeck fruits - Multi-action mechanism evidenced using animal and cell models

Medicine & Life Sciences

• Hesperidin 100%
• Synephrine 98%
• Citrus 88%
• Limonene 83%
• Fruit 62%
• Animal Models 47%
• Phytochemicals 23%
• Obesity 23%
• Hyperlipidemias 22%
• Hydroxymethylglutaryl-CoA Synthase 19%
• Cholesterol 16%
• Hydroxymethylglutaryl CoA Reductases 15%
• gamma-sitosterol 15%
• Acetyl-CoA Carboxylase 14%
• Hypolipidemic Agents 14%
• Fatty Acid Synthases 14%
• Volatile Oils 13%
• Sterols 12%
• Mixed Function Oxygenases 12%
• Hep G2 Cells 11%
• Taiwan 10%
• Wistar Rats 9%
• Life Style 8%
• Up-Regulation 7%
• Down-Regulation 7%
• Lipids 7%
• Membranes 6%
• Enzymes 6%
• Animals 5%
• Health 5%
• Incidence 5%

Agriculture & Biology

• Citrus maxima 95%
• hesperidin 91%
• limonene 60%
• animal models 57%
• mechanism of action 56%
• fruits 38%
• obesity 34%
• hyperlipidemia 27%
• cells 20%
• cholesterol 16%
• phytonutrients 16%
• sitosterols 14%
• fatty-acid synthase 14%
• acetyl-CoA carboxylase 13%
• carpels 13%
• pomace 13%
• lifestyle 11%
• Taiwan 10%
• risk factors 10%
• sterols 10%
• human health 10%
• phytochemicals 9%
• essential oils 9%
• excretion 8%
• incidence 7%
• biosynthesis 7%
• lipids 5%
• enzymes 4%
• testing 4%