Insulin secretagogue bioactivity of finger citron fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae)

Chiung Huei Peng, Yaw Bee Ker, Ching Feng Weng, Chiuno Chi Peng, Chien Ning Huang, L. I.Yun Lin, Robert Y. Peng

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72 Citations (Scopus)


Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables and preserved as sweetmeats. Previously we identified the major compounds in essential oils (% in EO) of FC fruits to be d-limonene (51.24), y-terpenene (33.71), α-pinene (3.40), and, β-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel to compositional analysis, we performed in vivo the safety, hypoglycemic, and antidiabetic tests in Sprague-DawleySPF rats and Wistar DIO rats respectively. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) and the insulin-glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed. In conclusion, FC fruits that concomitantly possess insulin secretagogue and slimming effects would be very beneficial to type 2 diabetes mellitus patients.

Original languageEnglish
Pages (from-to)8812-8819
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Issue number19
Publication statusPublished - 2009
Externally publishedYes


  • Antiobese
  • Finger citron fruits
  • Insulin secretagogue
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences


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