Abstract
Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables and preserved as sweetmeats. Previously we identified the major compounds in essential oils (% in EO) of FC fruits to be d-limonene (51.24), y-terpenene (33.71), α-pinene (3.40), and, β-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel to compositional analysis, we performed in vivo the safety, hypoglycemic, and antidiabetic tests in Sprague-DawleySPF rats and Wistar DIO rats respectively. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) and the insulin-glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed. In conclusion, FC fruits that concomitantly possess insulin secretagogue and slimming effects would be very beneficial to type 2 diabetes mellitus patients.
Original language | English |
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Pages (from-to) | 8812-8819 |
Number of pages | 8 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 57 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2009 |
Externally published | Yes |
Keywords
- Antiobese
- Finger citron fruits
- Insulin secretagogue
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Chemistry(all)