Insulin secretagogue bioactivity of finger citron fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae)

Chiung Huei Peng, Yaw Bee Ker, Ching Feng Weng, Chiuno Chi Peng, Chien Ning Huang, L. I Yun Lin, Robert Y. Peng

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58 Citations (Scopus)


Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables and preserved as sweetmeats. Previously we identified the major compounds in essential oils (% in EO) of FC fruits to be d-limonene (51.24), y-terpenene (33.71), α-pinene (3.40), and, β-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel to compositional analysis, we performed in vivo the safety, hypoglycemic, and antidiabetic tests in Sprague-DawleySPF rats and Wistar DIO rats respectively. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) and the insulin-glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed. In conclusion, FC fruits that concomitantly possess insulin secretagogue and slimming effects would be very beneficial to type 2 diabetes mellitus patients.

Original languageEnglish
Pages (from-to)8812-8819
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Issue number19
Publication statusPublished - 2009
Externally publishedYes


  • Antiobese
  • Finger citron fruits
  • Insulin secretagogue
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)


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