TY - JOUR
T1 - Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1- IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation
AU - Fujita, Masaaki
AU - Takada, Yoko K.
AU - Takada, Yoshikazu
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.
AB - Background: αvβ3 binds to IGF1, and the αvβ3-IGF1- IGF1R complex is formed in non-transformed cells. Results: IGF1 induces signals with the complex formation in anchorage independence. IGF1R or Src inhibitors did not suppress the complex formation. Conclusion: αvβ3-ECM interaction is not required for IGF signaling. The complex formation occurs before IGF1R activation. Significance: This study identifies new therapeutic targets in IGF signaling.
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U2 - 10.1074/jbc.M112.412536
DO - 10.1074/jbc.M112.412536
M3 - Article
C2 - 23243309
AN - SCOPUS:84873282225
SN - 0021-9258
VL - 288
SP - 3059
EP - 3069
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 5
ER -