Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Chien Liang Liu; Hung Tsung Wu; Yi Hsuan Hsiao; Chih Wei Lai; Chun Wei Shih; Yung Kang Peng; Kuo Chun Tang; Hsing Wei Chang; Yun Chen Chien; Jong Kai Hsiao; Juei Tang Cheng; Pi Tai Chou

doi:10.1002/anie.201100299

Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Chien Liang Liu, Hung Tsung Wu, Yi Hsuan Hsiao, Chih Wei Lai, Chun Wei Shih, Yung Kang Peng, Kuo Chun Tang, Hsing Wei Chang, Yun Chen Chien, Jong Kai Hsiao, Juei Tang Cheng, Pi Tai Chou

Research output: Contribution to journal › Article › peer-review

396 Citations (Scopus)

Abstract

Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

Original language	English
Pages (from-to)	7056-7060
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	31
DOIs	https://doi.org/10.1002/anie.201100299
Publication status	Published - Jul 25 2011
Externally published	Yes

Keywords

biomaterials
fluorescence
gold
imaging agents
nanostructures

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201100299

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Liu, C. L., Wu, H. T., Hsiao, Y. H., Lai, C. W., Shih, C. W., Peng, Y. K., Tang, K. C., Chang, H. W., Chien, Y. C., Hsiao, J. K., Cheng, J. T., & Chou, P. T. (2011). Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging. Angewandte Chemie - International Edition, 50(31), 7056-7060. https://doi.org/10.1002/anie.201100299

Liu, CL, Wu, HT, Hsiao, YH, Lai, CW, Shih, CW, Peng, YK, Tang, KC, Chang, HW, Chien, YC, Hsiao, JK, Cheng, JT & Chou, PT 2011, 'Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging', Angewandte Chemie - International Edition, vol. 50, no. 31, pp. 7056-7060. https://doi.org/10.1002/anie.201100299

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AU - Lai, Chih Wei

AU - Shih, Chun Wei

AU - Peng, Yung Kang

AU - Tang, Kuo Chun

AU - Chang, Hsing Wei

AU - Chien, Yun Chen

AU - Hsiao, Jong Kai

AU - Cheng, Juei Tang

AU - Chou, Pi Tai

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KW - gold

KW - imaging agents

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Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Abstract

Keywords

ASJC Scopus subject areas

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