Instability of spontaneous breathing patterns in patients with persistent vegetative state

Mauo Ying Bien; Huey Wen Yien; Shu Shya Hseu; Jia Horng Wang; Yu Ru Kou

doi:10.1016/j.resp.2004.09.007

Instability of spontaneous breathing patterns in patients with persistent vegetative state

Mauo Ying Bien, Huey Wen Yien, Shu Shya Hseu, Jia Horng Wang, Yu Ru Kou

School of Respiratory Therapy

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We investigated the breathing patterns of 27 patients in a persistent vegetative state (PVS) and 15 normal control volunteers. During the baseline period breathing air, 15 patients (the PVS-IB) exhibited irregular breathing (IB), whereas the other 12 (the PVS-OB) displayed oscillatory breathing (OB). Both groups maintained an average value for tidal volume (V_T), total breath duration (T_TOT), minute ventilation (V̇_E), oxygen saturation (SpO₂) similar to the control, but the PVS-OB displayed significantly lower end-tidal CO₂ tension (P _ETCO₂) than the control. The V_T, T _TOT, V̇_E and P_ETCO₂ of the PVS-OB showed cyclic changes. The coefficients of variation of V_T, T_TOT and V̇_I were: PVS-OB > PVS-IB > control. Inhalation of 100% O₂ significantly reduced the respiratory variability and prevented OB of the PVS-OB. We concluded that PVS patients display respiratory instability and that brain damage, hypocapnia, and/or increased loop gain of arterial chemoreceptors may contribute to the pathogenesis of OB, whereas brain damage presumably may be the cause of IB.

Original language	English
Pages (from-to)	163-175
Number of pages	13
Journal	Respiratory Physiology and Neurobiology
Volume	145
Issue number	2-3
DOIs	https://doi.org/10.1016/j.resp.2004.09.007
Publication status	Published - Feb 2005

Keywords

Brain damage
Control of breathing
Irregular breathing
Oscillatory breathing
Peripheral chemoreceptors
Respiratory plasticity

ASJC Scopus subject areas

General Neuroscience
Physiology
Pulmonary and Respiratory Medicine

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10.1016/j.resp.2004.09.007

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abstract = "We investigated the breathing patterns of 27 patients in a persistent vegetative state (PVS) and 15 normal control volunteers. During the baseline period breathing air, 15 patients (the PVS-IB) exhibited irregular breathing (IB), whereas the other 12 (the PVS-OB) displayed oscillatory breathing (OB). Both groups maintained an average value for tidal volume (VT), total breath duration (TTOT), minute ventilation ({\.V}E), oxygen saturation (SpO2) similar to the control, but the PVS-OB displayed significantly lower end-tidal CO2 tension (P ETCO2) than the control. The VT, T TOT, {\.V}E and PETCO2 of the PVS-OB showed cyclic changes. The coefficients of variation of VT, TTOT and {\.V}I were: PVS-OB > PVS-IB > control. Inhalation of 100% O2 significantly reduced the respiratory variability and prevented OB of the PVS-OB. We concluded that PVS patients display respiratory instability and that brain damage, hypocapnia, and/or increased loop gain of arterial chemoreceptors may contribute to the pathogenesis of OB, whereas brain damage presumably may be the cause of IB.",

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doi = "10.1016/j.resp.2004.09.007",

language = "English",

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AU - Kou, Yu Ru

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Instability of spontaneous breathing patterns in patients with persistent vegetative state

Abstract

Keywords

ASJC Scopus subject areas

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