TY - JOUR
T1 - Insomnia but Not Hypnotics Use Associates with the Risk of Breast Cancer
T2 - A Population-Based Matched Cohort Study
AU - Chiu, Hsiao Yean
AU - Huang, Chun Jen
AU - Fan, Yen Chun
AU - Tsai, Pei Shan
N1 - Publisher Copyright:
© 2018, Mary Ann Liebert, Inc., publishers.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Objective: The impact of hypnotic use on the association between insomnia and breast cancer risk remains unclear. This study examined whether insomnia increases the aforementioned risk and explored the effects of hypnotic use on this relationship. Materials and Methods: This retrospective cohort study was conducted using data retrieved from the Longitudinal Health Insurance Research Database 2010. In total, 11,021 patients with insomnia, who were categorized by hypnotic use and nonuse, were identified; 22,042 age-matched participants without insomnia were then randomly selected. Cox proportional hazards regression was used for the analyses. Results: The insomnia cohort had a higher risk of breast cancer than did the control cohort (adjusted hazard ratio [aHR] = 1.43; 95% confidence interval [CI] = 1.10-1.84). The aHR was 1.09 for insomniac with hypnotics use, 1.41 for insomniac without hypnotics use, and 0.71 for hypnotics users without insomnia (95% CIs = 0.71-1.68, 1.07-1.85, and 0.40-1.27) compared with those individuals without insomnia who did not use hypnotics. Conclusion: This nationwide population-based cohort study reveals that insomnia but not hypnotic use is associated with an increased risk of breast cancer.
AB - Objective: The impact of hypnotic use on the association between insomnia and breast cancer risk remains unclear. This study examined whether insomnia increases the aforementioned risk and explored the effects of hypnotic use on this relationship. Materials and Methods: This retrospective cohort study was conducted using data retrieved from the Longitudinal Health Insurance Research Database 2010. In total, 11,021 patients with insomnia, who were categorized by hypnotic use and nonuse, were identified; 22,042 age-matched participants without insomnia were then randomly selected. Cox proportional hazards regression was used for the analyses. Results: The insomnia cohort had a higher risk of breast cancer than did the control cohort (adjusted hazard ratio [aHR] = 1.43; 95% confidence interval [CI] = 1.10-1.84). The aHR was 1.09 for insomniac with hypnotics use, 1.41 for insomniac without hypnotics use, and 0.71 for hypnotics users without insomnia (95% CIs = 0.71-1.68, 1.07-1.85, and 0.40-1.27) compared with those individuals without insomnia who did not use hypnotics. Conclusion: This nationwide population-based cohort study reveals that insomnia but not hypnotic use is associated with an increased risk of breast cancer.
KW - breast cancer
KW - hypnotic use
KW - insomnia
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U2 - 10.1089/jwh.2017.6626
DO - 10.1089/jwh.2017.6626
M3 - Article
C2 - 29634447
AN - SCOPUS:85051234501
SN - 1540-9996
VL - 27
SP - 1250
EP - 1256
JO - Journal of Women's Health
JF - Journal of Women's Health
IS - 10
ER -