Insights into Metabolic Reprogramming in Tumor Evolution and Therapy

Ching Feng Chiu, Jonathan Jaime G. Guerrero, Ric Ryan H. Regalado, Ma Joy B. Zamora, Jiayan Zhou, Kin Israel Notarte, Yu Wei Lu, Paolo C. Encarnacion, Cidne Danielle D. Carles, Edrian M. Octavo, Dan Christopher I. Limbaroc, Charupong Saengboonmee, Shih Yi Huang

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Cancer remains a global health challenge, characterized not just by uncontrolled cell proliferation but also by the complex metabolic reprogramming that underlies its development and progression. Objectives: This review delves into the intricate relationship between cancer and its metabolic alterations, drawing an innovative comparison with the cosmological concepts of dark matter and dark energy to highlight the pivotal yet often overlooked role of metabolic reprogramming in tumor evolution. Methods: It scrutinizes the Warburg effect and other metabolic adaptations, such as shifts in lipid synthesis, amino acid turnover, and mitochondrial function, driven by mutations in key regulatory genes. Results: This review emphasizes the significance of targeting these metabolic pathways for therapeutic intervention, outlining the potential to disrupt cancer’s energy supply and signaling mechanisms. It calls for an interdisciplinary research approach to fully understand and exploit the intricacies of cancer metabolism, pointing toward metabolic reprogramming as a promising frontier for developing more effective cancer treatments. Conclusion: By equating cancer’s metabolic complexity with the enigmatic nature of dark matter and energy, this review underscores the critical need for innovative strategies in oncology, highlighting the importance of unveiling and targeting the “dark energy” within cancer cells to revolutionize future therapy and research.

Original languageEnglish
Article number3513
JournalCancers
Volume16
Issue number20
DOIs
Publication statusPublished - Oct 2024

Keywords

  • cancer
  • metabolic reprogramming
  • Warburg effect

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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