Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

Hsueh Yun Lee; Chia-Ron Yang; Mei-Jung Lai; Han-Li Huang; Yi-Ling Hsieh; Yi-Min Liu; Teng-Kuang Yeh; Yu-Hsuan Li; Samir Mehndiratta; Che-Ming Teng; Jing Ping Liou

doi:10.1002/cbic.201390034

Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

Hsueh Yun Lee, Chia-Ron Yang, Mei-Jung Lai, Han-Li Huang, Yi-Ling Hsieh, Yi-Min Liu, Teng-Kuang Yeh, Yu-Hsuan Li, Samir Mehndiratta, Che-Ming Teng, Jing Ping Liou

Research output: Contribution to journal › Article › peer-review

Abstract

The inside cover picture shows a SAR study of synthetic N-hydroxyacrylamides, described by J.-P. Liou et al. on p. 1248 ff., that identified 3-[1- (4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-5-yl]-N-hydroxyacrylamide as a potent HDAC inhibitor. This compound not only suppresses the production of lipopolysaccharide-induced cytokines but also markedly reduces carrageenan-induced inflammation in rat.

Original language	English
Pages (from-to)	1150
Number of pages	1
Journal	ChemBioChem
Volume	14
Issue number	10
DOIs	https://doi.org/10.1002/cbic.201390034
Publication status	Published - Jul 2013

Keywords

Anti-inflammatory agents
Gene expression
Histone deacetylase
Indolines
Inhibitors

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Molecular Medicine
Molecular Biology

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10.1002/cbic.201390034

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Lee, H. Y., Yang, C.-R., Lai, M.-J., Huang, H.-L., Hsieh, Y.-L., Liu, Y.-M., Yeh, T.-K., Li, Y.-H., Mehndiratta, S., Teng, C.-M., & Liou, J. P. (2013). Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013). ChemBioChem, 14(10), 1150. https://doi.org/10.1002/cbic.201390034

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abstract = "The inside cover picture shows a SAR study of synthetic N-hydroxyacrylamides, described by J.-P. Liou et al. on p. 1248 ff., that identified 3-[1- (4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-5-yl]-N-hydroxyacrylamide as a potent HDAC inhibitor. This compound not only suppresses the production of lipopolysaccharide-induced cytokines but also markedly reduces carrageenan-induced inflammation in rat.",

keywords = "Anti-inflammatory agents, Gene expression, Histone deacetylase, Indolines, Inhibitors, Anti-inflammatory agents, Gene expression, Histone deacetylase, Indolines, Inhibitors",

author = "Lee, {Hsueh Yun} and Chia-Ron Yang and Mei-Jung Lai and Han-Li Huang and Yi-Ling Hsieh and Yi-Min Liu and Teng-Kuang Yeh and Yu-Hsuan Li and Samir Mehndiratta and Che-Ming Teng and Liou, {Jing Ping}",

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T2 - 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

AU - Lee, Hsueh Yun

AU - Yang, Chia-Ron

AU - Lai, Mei-Jung

AU - Huang, Han-Li

AU - Hsieh, Yi-Ling

AU - Liu, Yi-Min

AU - Yeh, Teng-Kuang

AU - Li, Yu-Hsuan

AU - Mehndiratta, Samir

AU - Teng, Che-Ming

AU - Liou, Jing Ping

PY - 2013/7

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N2 - The inside cover picture shows a SAR study of synthetic N-hydroxyacrylamides, described by J.-P. Liou et al. on p. 1248 ff., that identified 3-[1- (4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-5-yl]-N-hydroxyacrylamide as a potent HDAC inhibitor. This compound not only suppresses the production of lipopolysaccharide-induced cytokines but also markedly reduces carrageenan-induced inflammation in rat.

AB - The inside cover picture shows a SAR study of synthetic N-hydroxyacrylamides, described by J.-P. Liou et al. on p. 1248 ff., that identified 3-[1- (4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-5-yl]-N-hydroxyacrylamide as a potent HDAC inhibitor. This compound not only suppresses the production of lipopolysaccharide-induced cytokines but also markedly reduces carrageenan-induced inflammation in rat.

KW - Anti-inflammatory agents

KW - Gene expression

KW - Histone deacetylase

KW - Indolines

KW - Inhibitors

KW - Anti-inflammatory agents

KW - Gene expression

KW - Histone deacetylase

KW - Indolines

KW - Inhibitors

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Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)

Abstract

Keywords

ASJC Scopus subject areas

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