Inhibitory effects of far-infrared irradiation generated by ceramic material on murine melanoma cell growth

Ting Kai Leung; Chin Feng Chan; Ping Shan Lai; Chih Hui Yang; Chia Yen Hsu; Yung Sheng Lin

doi:10.1155/2012/646845

Inhibitory effects of far-infrared irradiation generated by ceramic material on murine melanoma cell growth

Ting Kai Leung, Chin Feng Chan, Ping Shan Lai, Chih Hui Yang, Chia Yen Hsu, Yung Sheng Lin

Taipei Medical University Hospital

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The biological effects of specific wavelengths, so-called far-infrared radiation produced from ceramic material (cFIR), on whole organisms are not yet well understood. In this study, we investigated the biological effects of cFIR on murine melanoma cells (B16-F10) at body temperature. cFIR irradiation treatment for 48h resulted in an 11.8% decrease in the proliferation of melanoma cells relative to the control. Meanwhile, incubation of cells with cFIR for 48h significantly resulted in 56.9% and 15.7% decreases in the intracellular heat shock protein (HSP)70 and intracellular nitric oxide (iNO) contents, respectively. Furthermore, cFIR treatment induced 6.4% and 12.3% increases in intracellular reactive oxygen species stained by 5-(and 6)-carboxyl- 2 ′, 7 ′ -dichlorodihydrofluorescein diacetate and dihydrorhodamine 123, respectively. Since malignant melanomas are known to have high HSP70 expression and iNO activity, the suppressive effects of cFIR on HSP70 and NO may warrant future interest in antitumor applications.

Original language	English
Article number	646845
Journal	International Journal of Photoenergy
Volume	2012
DOIs	https://doi.org/10.1155/2012/646845
Publication status	Published - 2012

ASJC Scopus subject areas

Renewable Energy, Sustainability and the Environment
Chemistry(all)
Atomic and Molecular Physics, and Optics
Materials Science(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1155/2012/646845

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title = "Inhibitory effects of far-infrared irradiation generated by ceramic material on murine melanoma cell growth",

abstract = "The biological effects of specific wavelengths, so-called far-infrared radiation produced from ceramic material (cFIR), on whole organisms are not yet well understood. In this study, we investigated the biological effects of cFIR on murine melanoma cells (B16-F10) at body temperature. cFIR irradiation treatment for 48h resulted in an 11.8% decrease in the proliferation of melanoma cells relative to the control. Meanwhile, incubation of cells with cFIR for 48h significantly resulted in 56.9% and 15.7% decreases in the intracellular heat shock protein (HSP)70 and intracellular nitric oxide (iNO) contents, respectively. Furthermore, cFIR treatment induced 6.4% and 12.3% increases in intracellular reactive oxygen species stained by 5-(and 6)-carboxyl- 2 ′, 7 ′ -dichlorodihydrofluorescein diacetate and dihydrorhodamine 123, respectively. Since malignant melanomas are known to have high HSP70 expression and iNO activity, the suppressive effects of cFIR on HSP70 and NO may warrant future interest in antitumor applications.",

author = "Leung, {Ting Kai} and Chan, {Chin Feng} and Lai, {Ping Shan} and Yang, {Chih Hui} and Hsu, {Chia Yen} and Lin, {Yung Sheng}",

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doi = "10.1155/2012/646845",

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AU - Leung, Ting Kai

AU - Chan, Chin Feng

AU - Lai, Ping Shan

AU - Yang, Chih Hui

AU - Hsu, Chia Yen

AU - Lin, Yung Sheng

PY - 2012

Y1 - 2012

N2 - The biological effects of specific wavelengths, so-called far-infrared radiation produced from ceramic material (cFIR), on whole organisms are not yet well understood. In this study, we investigated the biological effects of cFIR on murine melanoma cells (B16-F10) at body temperature. cFIR irradiation treatment for 48h resulted in an 11.8% decrease in the proliferation of melanoma cells relative to the control. Meanwhile, incubation of cells with cFIR for 48h significantly resulted in 56.9% and 15.7% decreases in the intracellular heat shock protein (HSP)70 and intracellular nitric oxide (iNO) contents, respectively. Furthermore, cFIR treatment induced 6.4% and 12.3% increases in intracellular reactive oxygen species stained by 5-(and 6)-carboxyl- 2 ′, 7 ′ -dichlorodihydrofluorescein diacetate and dihydrorhodamine 123, respectively. Since malignant melanomas are known to have high HSP70 expression and iNO activity, the suppressive effects of cFIR on HSP70 and NO may warrant future interest in antitumor applications.

AB - The biological effects of specific wavelengths, so-called far-infrared radiation produced from ceramic material (cFIR), on whole organisms are not yet well understood. In this study, we investigated the biological effects of cFIR on murine melanoma cells (B16-F10) at body temperature. cFIR irradiation treatment for 48h resulted in an 11.8% decrease in the proliferation of melanoma cells relative to the control. Meanwhile, incubation of cells with cFIR for 48h significantly resulted in 56.9% and 15.7% decreases in the intracellular heat shock protein (HSP)70 and intracellular nitric oxide (iNO) contents, respectively. Furthermore, cFIR treatment induced 6.4% and 12.3% increases in intracellular reactive oxygen species stained by 5-(and 6)-carboxyl- 2 ′, 7 ′ -dichlorodihydrofluorescein diacetate and dihydrorhodamine 123, respectively. Since malignant melanomas are known to have high HSP70 expression and iNO activity, the suppressive effects of cFIR on HSP70 and NO may warrant future interest in antitumor applications.

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Inhibitory effects of far-infrared irradiation generated by ceramic material on murine melanoma cell growth

Abstract

ASJC Scopus subject areas

UN SDGs

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