Influences of cardiac mechano-electrical feedback on action potential duration

J. C. Hsieh; Shih Ann Chen; Cheng Jeng Tai; John K J Li

Influences of cardiac mechano-electrical feedback on action potential duration

J. C. Hsieh, Shih Ann Chen, Cheng Jeng Tai, John K J Li

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (I_cl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of I_cl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.

Original language	English
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Publisher	IEEE
Pages	142
Number of pages	1
Volume	1
ISBN (Print)	0780356756
Publication status	Published - 1999
Externally published	Yes
Event	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA Duration: Oct 13 1999 → Oct 16 1999

Other

Other	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
City	Atlanta, GA, USA
Period	10/13/99 → 10/16/99

ASJC Scopus subject areas

Bioengineering

Cite this

Hsieh, JC, Chen, SA, Tai, CJ & Li, JKJ 1999, Influences of cardiac mechano-electrical feedback on action potential duration. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, IEEE, pp. 142, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.

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abstract = "A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (Icl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of Icl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.",

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year = "1999",

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booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

publisher = "IEEE",

note = "Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) ; Conference date: 13-10-1999 Through 16-10-1999",

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AU - Hsieh, J. C.

AU - Chen, Shih Ann

AU - Tai, Cheng Jeng

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Y1 - 1999

N2 - A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (Icl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of Icl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.

AB - A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (Icl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of Icl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.

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Influences of cardiac mechano-electrical feedback on action potential duration

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