Influence of hyperbaric oxygen on tumor necrosis factor-α and nitric oxide production in endotoxin-induced acute lung injury in rats

Shi Jye Chu; Min Hui Li; Ching Wang Hsu; Shih Hung Tsai; Shih Hua Lin; Kun Lun Huang

doi:10.1016/j.pupt.2006.08.009

Influence of hyperbaric oxygen on tumor necrosis factor-α and nitric oxide production in endotoxin-induced acute lung injury in rats

Shi Jye Chu
, Min Hui Li
, Ching Wang Hsu
, Shih Hung Tsai
, Shih Hua Lin
, Kun Lun Huang

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We previously demonstrated that hyperbaric oxygen (HBO) treatment alleviated lipopolysaccharide (LPS)-induced acute lung injury in rats. However, the mechanisms responsible for the protective effect are still not fully understood. To obtain further information on the protective effect of HBO, in this study we investigated the role of tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in intratracheal spraying LPS-induced acute lung injury in rats after HBO or hyperoxia treatment. The results showed that HBO but not hyperoxia attenuated the TNF-α level in plasma and bronchoalveolar lavage (BAL) fluid, NO concentration in BAL and plasma, and inducible NO synthase protein expression in lung tissue based on the Western blotting and immunohistochemical staining.

Original language	English
Pages (from-to)	684-690
Number of pages	7
Journal	Pulmonary Pharmacology and Therapeutics
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/j.pupt.2006.08.009
Publication status	Published - Dec 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute lung injury
Hyperbaric oxygen
Nitric oxide
Tumor necrosis factor-α

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Biochemistry, medical
Pharmacology (medical)

Access to Document

10.1016/j.pupt.2006.08.009

Cite this

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title = "Influence of hyperbaric oxygen on tumor necrosis factor-α and nitric oxide production in endotoxin-induced acute lung injury in rats",

abstract = "We previously demonstrated that hyperbaric oxygen (HBO) treatment alleviated lipopolysaccharide (LPS)-induced acute lung injury in rats. However, the mechanisms responsible for the protective effect are still not fully understood. To obtain further information on the protective effect of HBO, in this study we investigated the role of tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in intratracheal spraying LPS-induced acute lung injury in rats after HBO or hyperoxia treatment. The results showed that HBO but not hyperoxia attenuated the TNF-α level in plasma and bronchoalveolar lavage (BAL) fluid, NO concentration in BAL and plasma, and inducible NO synthase protein expression in lung tissue based on the Western blotting and immunohistochemical staining.",

keywords = "Acute lung injury, Hyperbaric oxygen, Nitric oxide, Tumor necrosis factor-α",

author = "Chu, \{Shi Jye\} and Li, \{Min Hui\} and Hsu, \{Ching Wang\} and Tsai, \{Shih Hung\} and Lin, \{Shih Hua\} and Huang, \{Kun Lun\}",

year = "2007",

month = dec,

doi = "10.1016/j.pupt.2006.08.009",

language = "English",

volume = "20",

pages = "684--690",

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TY - JOUR

T1 - Influence of hyperbaric oxygen on tumor necrosis factor-α and nitric oxide production in endotoxin-induced acute lung injury in rats

AU - Chu, Shi Jye

AU - Li, Min Hui

AU - Hsu, Ching Wang

AU - Tsai, Shih Hung

AU - Lin, Shih Hua

AU - Huang, Kun Lun

PY - 2007/12

Y1 - 2007/12

N2 - We previously demonstrated that hyperbaric oxygen (HBO) treatment alleviated lipopolysaccharide (LPS)-induced acute lung injury in rats. However, the mechanisms responsible for the protective effect are still not fully understood. To obtain further information on the protective effect of HBO, in this study we investigated the role of tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in intratracheal spraying LPS-induced acute lung injury in rats after HBO or hyperoxia treatment. The results showed that HBO but not hyperoxia attenuated the TNF-α level in plasma and bronchoalveolar lavage (BAL) fluid, NO concentration in BAL and plasma, and inducible NO synthase protein expression in lung tissue based on the Western blotting and immunohistochemical staining.

AB - We previously demonstrated that hyperbaric oxygen (HBO) treatment alleviated lipopolysaccharide (LPS)-induced acute lung injury in rats. However, the mechanisms responsible for the protective effect are still not fully understood. To obtain further information on the protective effect of HBO, in this study we investigated the role of tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in intratracheal spraying LPS-induced acute lung injury in rats after HBO or hyperoxia treatment. The results showed that HBO but not hyperoxia attenuated the TNF-α level in plasma and bronchoalveolar lavage (BAL) fluid, NO concentration in BAL and plasma, and inducible NO synthase protein expression in lung tissue based on the Western blotting and immunohistochemical staining.

KW - Acute lung injury

KW - Hyperbaric oxygen

KW - Nitric oxide

KW - Tumor necrosis factor-α

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UR - https://www.scopus.com/pages/publications/34548827340#tab=citedBy

U2 - 10.1016/j.pupt.2006.08.009

DO - 10.1016/j.pupt.2006.08.009

M3 - Article

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AN - SCOPUS:34548827340

SN - 1094-5539

VL - 20

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EP - 690

JO - Pulmonary Pharmacology and Therapeutics

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Influence of hyperbaric oxygen on tumor necrosis factor-α and nitric oxide production in endotoxin-induced acute lung injury in rats

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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