Abstract
We previously demonstrated that hyperbaric oxygen (HBO) treatment alleviated lipopolysaccharide (LPS)-induced acute lung injury in rats. However, the mechanisms responsible for the protective effect are still not fully understood. To obtain further information on the protective effect of HBO, in this study we investigated the role of tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in intratracheal spraying LPS-induced acute lung injury in rats after HBO or hyperoxia treatment. The results showed that HBO but not hyperoxia attenuated the TNF-α level in plasma and bronchoalveolar lavage (BAL) fluid, NO concentration in BAL and plasma, and inducible NO synthase protein expression in lung tissue based on the Western blotting and immunohistochemical staining.
Original language | English |
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Pages (from-to) | 684-690 |
Number of pages | 7 |
Journal | Pulmonary Pharmacology and Therapeutics |
Volume | 20 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2007 |
Externally published | Yes |
Keywords
- Acute lung injury
- Hyperbaric oxygen
- Nitric oxide
- Tumor necrosis factor-α
ASJC Scopus subject areas
- Biochemistry, medical
- Pharmacology (medical)
- Pulmonary and Respiratory Medicine