Abstract
Background and Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese. Methods: Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls. Results: Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age
Original language | English |
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Pages (from-to) | 301-307 |
Number of pages | 7 |
Journal | Journal of Surgical Oncology |
Volume | 102 |
Issue number | 4 |
DOIs | |
Publication status | Published - Sept 15 2010 |
Externally published | Yes |
Keywords
- Glutathione-S-transferases
- Hepatocellular carcinoma
- Single nucleotide polymorphism
ASJC Scopus subject areas
- Surgery
- Oncology