Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan

Chia Chun Kao; M. U Kuan Chen; W. U Hsien Kuo; Tzy Yen Chen; Shih Chi Su; Y. I Hsien Hsieh; Chuen Lan Liu; Ming Chih Chou; Hsiu Ting Tsai; Shun F A Yang

doi:10.1002/jso.21643

Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan

Chia Chun Kao, M. U Kuan Chen, W. U Hsien Kuo, Tzy Yen Chen, Shih Chi Su, Y. I Hsien Hsieh, Chuen Lan Liu, Ming Chih Chou, Hsiu Ting Tsai, Shun F A Yang

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background and Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese. Methods: Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls. Results: Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age

Original language	English
Pages (from-to)	301-307
Number of pages	7
Journal	Journal of Surgical Oncology
Volume	102
Issue number	4
DOIs	https://doi.org/10.1002/jso.21643
Publication status	Published - Sept 15 2010
Externally published	Yes

Keywords

Glutathione-S-transferases
Hepatocellular carcinoma
Single nucleotide polymorphism

ASJC Scopus subject areas

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.21643

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Kao, C. C., Chen, M. U. K., Kuo, W. U. H., Chen, T. Y., Su, S. C., Hsieh, Y. I. H., Liu, C. L., Chou, M. C., Tsai, H. T., & Yang, S. F. A. (2010). Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan. Journal of Surgical Oncology, 102(4), 301-307. https://doi.org/10.1002/jso.21643

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title = "Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan",

abstract = "Background and Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese. Methods: Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls. Results: Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age ",

keywords = "Glutathione-S-transferases, Hepatocellular carcinoma, Single nucleotide polymorphism",

author = "Kao, {Chia Chun} and Chen, {M. U Kuan} and Kuo, {W. U Hsien} and Chen, {Tzy Yen} and Su, {Shih Chi} and Hsieh, {Y. I Hsien} and Liu, {Chuen Lan} and Chou, {Ming Chih} and Tsai, {Hsiu Ting} and Yang, {Shun F A}",

year = "2010",

month = sep,

day = "15",

doi = "10.1002/jso.21643",

language = "English",

volume = "102",

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AU - Kao, Chia Chun

AU - Chen, M. U Kuan

AU - Kuo, W. U Hsien

AU - Chen, Tzy Yen

AU - Su, Shih Chi

AU - Hsieh, Y. I Hsien

AU - Liu, Chuen Lan

AU - Chou, Ming Chih

AU - Tsai, Hsiu Ting

AU - Yang, Shun F A

PY - 2010/9/15

Y1 - 2010/9/15

N2 - Background and Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese. Methods: Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls. Results: Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age

AB - Background and Objectives: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of HCC. Glutathione-S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and HCC risk and clinicopathological status in Taiwanese. Methods: Polymerase chain reaction (PCR) was used to determine gene polymorphisms of 102 patients with HCC and 386 healthy controls. Results: Both gene polymorphisms were not associated with the clinical pathological status of HCC and serum levels of liver-related clinical pathological markers. While no relationship between GSTM1 gene polymorphism and HCC susceptibility was found, individuals of age

KW - Glutathione-S-transferases

KW - Hepatocellular carcinoma

KW - Single nucleotide polymorphism

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Influence of glutathione-S-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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