Influence of a 100-km ultra-marathon on hepatitis B carrier runners

Y. H. Chiu, S. K. Hou, C. K. How, L. H. Li, W. F. Kao, C. C. Yang, S. L. Chou, Y. T S Shiau, C. Lam, R. J. Chen

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


This study compares the serological markers between runners who are hepatitis B virus carries (HBVc) and runners who are non-HBVc in a 100-km ultra-marathon race. Blood samples of 8 HBVc and 18 non-HBVc runners were drawn 1 week before, immediately following, and 24 h after the race. Samples were analyzed and compared between the 2 groups for liver function tests, muscle damage markers and oxidative stress cytokines. For HBVc runners, HBV-DNA (hepatitis B virus-deoxyribonucleic acid) levels were also evaluated for virus reactivation. The results demonstrate a statistically significant increase in both immediate and 24-h post-race values for alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), compared with pre-race values. No statistically significant difference was observed between the 2 groups for the values of AST, LDH, CK, hs-CRP, IL-6 and TNF-α either before or after the race. There was also no statistically significant change in the levels of HBV-DNA in HBVc runners. These findings suggest that HBVc runners do not have higher risks of liver function impairment, muscle breakdown and inflammatory response compared to non-HBVc runners in such endurance races.

Original languageEnglish
Pages (from-to)841-845
Number of pages5
JournalInternational Journal of Sports Medicine
Issue number9
Publication statusPublished - 2013


  • clinical sports medicine
  • hepatitis B virus carrier runner
  • inflammatory response
  • liver function impairment
  • ultra-marathon

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine


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