Abstract
Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p
Original language | English |
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Pages (from-to) | 746-752 |
Number of pages | 7 |
Journal | Journal of Clinical Immunology |
Volume | 32 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 2012 |
Externally published | Yes |
Keywords
- Coronary artery lesion
- Hemoglobin
- Hepcidin
- IL-6
- Iron
- Kawasaki disease
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology