Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease

Ho Chang Kuo; Ya Ling Yang; Jiin Haur Chuang; Mao Meng Tiao; Hong Ren Yu; Li Tung Huang; Kuender D. Yang; Wei Chiao Chang; Chiu Ping Lee; Ying Hsien Huang

doi:10.1007/s10875-012-9668-1

Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease

Ho Chang Kuo, Ya Ling Yang, Jiin Haur Chuang, Mao Meng Tiao, Hong Ren Yu, Li Tung Huang, Kuender D. Yang, Wei Chiao Chang, Chiu Ping Lee, Ying Hsien Huang

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p

Original language	English
Pages (from-to)	746-752
Number of pages	7
Journal	Journal of Clinical Immunology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1007/s10875-012-9668-1
Publication status	Published - Aug 2012
Externally published	Yes

Keywords

Coronary artery lesion
Hemoglobin
Hepcidin
IL-6
Iron
Kawasaki disease

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1007/s10875-012-9668-1

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title = "Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease",

abstract = "Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p",

keywords = "Coronary artery lesion, Hemoglobin, Hepcidin, IL-6, Iron, Kawasaki disease",

author = "Kuo, {Ho Chang} and Yang, {Ya Ling} and Chuang, {Jiin Haur} and Tiao, {Mao Meng} and Yu, {Hong Ren} and Huang, {Li Tung} and Yang, {Kuender D.} and Chang, {Wei Chiao} and Lee, {Chiu Ping} and Huang, {Ying Hsien}",

year = "2012",

month = aug,

doi = "10.1007/s10875-012-9668-1",

language = "English",

volume = "32",

pages = "746--752",

journal = "Journal of Clinical Immunology",

issn = "0271-9142",

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TY - JOUR

T1 - Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease

AU - Kuo, Ho Chang

AU - Yang, Ya Ling

AU - Chuang, Jiin Haur

AU - Tiao, Mao Meng

AU - Yu, Hong Ren

AU - Huang, Li Tung

AU - Yang, Kuender D.

AU - Chang, Wei Chiao

AU - Lee, Chiu Ping

AU - Huang, Ying Hsien

PY - 2012/8

Y1 - 2012/8

N2 - Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p

AB - Purpose Kawasaki disease (KD) is a systemic febrile vasculitis complicated by coronary artery lesions (CAL). Anemia is common in patients with KD and is associated with a prolonged duration of active inflammation. Hepcidin is a central modulator of inflammation-associated anemia, acting via control of iron absorption and a direct inhibitory effect on erythropoiesis. The aims of this study were to investigate the role of inflammation-induced hepcidin in the development of anemia, the occurrence of CAL formation, and IVIG treatment response in patients with KD. Methods Eighty-six KD patients and 30 febrile controls were enrolled. Levels of interleukin (IL)-6 and serumhepcidin were measured in sera by enzyme-linked immunosorbent assay. Hemoglobin and serum iron levels were also measured. Results Hemoglobin and iron levels were lower in KD patients than in controls (p

KW - Coronary artery lesion

KW - Hemoglobin

KW - Hepcidin

KW - IL-6

KW - Iron

KW - Kawasaki disease

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SN - 0271-9142

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JO - Journal of Clinical Immunology

JF - Journal of Clinical Immunology

IS - 4

ER -

Inflammation-induced hepcidin is associated with the development of anemia and coronary artery lesions in kawasaki disease

Abstract

Keywords

ASJC Scopus subject areas

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