Inflammation and renal function decline in chronic coronary syndrome: a prospective multicenter cohort study

Ting Wei Kao, Chin Chou Huang, Hsin Bang Leu, Wei Hsian Yin, Wei Kung Tseng, Yen Wen Wu, Tsung Hsien Lin, Hung I. Yeh, Kuan Cheng Chang, Ji Hung Wang, Chau Chung Wu, Jaw Wen Chen

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Renal function decline is a frequently encountered complication in patients with chronic coronary syndrome. Aside from traditional cardiovascular risk factors, the inflammatory burden emerged as the novel phenotype that compromised renal prognosis in such population. Methods: A cohort with chronic coronary syndrome was enrolled to investigate the association between inflammatory status and renal dysfunction. Levels of inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), tumour necrosis factor-α (TNF-α), adiponectin, matrix metalloproteinase-9, interleukin-6, lipoprotein-associated phospholipase A2, were assessed. Renal event was defined as > 25% decline in estimated glomerular filtration rate (eGFR). Inflammatory scores were calculated based on the aggregate of hs-CRP, TNF-α, and adiponectin levels. Results: Among the 850 enrolled subjects, 145 patients sustained a renal event during an averaged 3.5 years follow-up. Multivariate analysis with Cox regression suggested elevations in hs-CRP, TNF-α, and adiponectin levels were independent risk factors for the occurrence of a renal event. Whereas, Kaplan-Meier curve illustrated significant correlation between high TNF-α (P = 0.005), adiponectin (P < 0.001), but not hs-CRP (P = 0.092), and eGFR decline. The aggregative effect of these biomarkers was also distinctly correlated with renal events (score 2: P = 0.042; score 3: P < 0.001). Conclusions: Inflammatory burden was associated with eGFR decline in patients with chronic coronary syndrome.

Original languageEnglish
Article number564
JournalBMC Cardiovascular Disorders
Volume23
Issue number1
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Biomarker
  • Chronic coronary syndrome
  • Coronary artery Disease
  • Inflammation
  • Renal function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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