Induction of Interleukin-19 and Interleukin-22 After Cardiac Surgery With Cardiopulmonary Bypass

Chung-Hsi Hsing, Mei Yi Hsieh, Wei Yu Chen, Edmund Cheung So, Bor Chih Cheng, Ming Shi Chang

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Background: Interleukin (IL)-19, IL-20, and IL-22, three novel cytokines in the IL-10 family, have recently been discovered. The biological functions and clinical implications of these cytokines are not clear. We aimed to analyze if serum levels of these cytokines were altered in inflammatory responses of postoperative cardiopulmonary bypass (CPB) and investigate the molecular mechanism involved in cytokine induction. Methods: Twenty-five patients undergoing elective aortic-coronary bypass grafting with CPB were enrolled in this study. Blood samples withdrawn at (T1) before anesthesia, (T2) CPB start, (T3) CPB end, (T4) 4 hours post-CPB, (T5) 8 hours post-CPB, (T6) 12 hours post-CPB, (T7) 24 hours post-CPB, and (T8) 48 hours post-CPB were assayed for IL-6, IL-10, IL-19, IL-20, IL-22, and tumor necrotic factor-α (TNF-α). Transcripts of IL-19, IL-20, and IL-22 from monocytes were analyzed. In vitro, levels of IL-19, IL-20, and IL-22 production in monocytes incubated with IL-6 and TNF-α were determined. Results: The serum levels of IL-19 and IL-22 significantly increased at T3, peaked at T5, and remained increased at T8 (p

Original languageEnglish
Pages (from-to)2196-2201
Number of pages6
JournalAnnals of Thoracic Surgery
Issue number6
Publication statusPublished - Jun 2006
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


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