Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21

Yu Fang Kuang; Yue-Hwa Chen

doi:10.1016/j.fct.2004.06.009

Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21

Yu Fang Kuang, Yue-Hwa Chen

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC (â

Original language	English
Pages (from-to)	1711-1718
Number of pages	8
Journal	Food and Chemical Toxicology
Volume	42
Issue number	10
DOIs	https://doi.org/10.1016/j.fct.2004.06.009
Publication status	Published - Oct 2004

Keywords

Apoptosis
Indole-3-carbinol
Isothiocyanate
Lung adenocarcinoma A549 cells
P21
P53

ASJC Scopus subject areas

Food Science
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fct.2004.06.009

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abstract = "This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC ({\^a}",

keywords = "Apoptosis, Indole-3-carbinol, Isothiocyanate, Lung adenocarcinoma A549 cells, P21, P53",

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N2 - This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC (â

AB - This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC (â

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KW - Indole-3-carbinol

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KW - Lung adenocarcinoma A549 cells

KW - P21

KW - P53

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Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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