Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Yuh Cherng Guo; Che Mai Chang; Wen Li Hsu; Siou Jin Chiu; Yao Ting Tsai; Yii Her Chou; Ming Feng Hou; Jaw Yan Wang; Mei Hsien Lee; Ke Li Tsai; Wei Chiao Chang

doi:10.3390/molecules18066584

Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Yuh Cherng Guo
, Che Mai Chang
, Wen Li Hsu
, Siou Jin Chiu
, Yao Ting Tsai
, Yii Her Chou
, Ming Feng Hou
, Jaw Yan Wang
, Mei Hsien Lee
, Ke Li Tsai
, Wei Chiao Chang

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca²⁺ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

Original language	English
Pages (from-to)	6584-6596
Number of pages	13
Journal	Molecules
Volume	18
Issue number	6
DOIs	https://doi.org/10.3390/molecules18066584
Publication status	Published - Jun 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COX-2
Cell migration
EGF
Indomethacin

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules18066584

Cite this

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title = "Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization",

abstract = "Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.",

keywords = "COX-2, Cell migration, EGF, Indomethacin",

author = "Guo, \{Yuh Cherng\} and Chang, \{Che Mai\} and Hsu, \{Wen Li\} and Chiu, \{Siou Jin\} and Tsai, \{Yao Ting\} and Chou, \{Yii Her\} and Hou, \{Ming Feng\} and Wang, \{Jaw Yan\} and Lee, \{Mei Hsien\} and Tsai, \{Ke Li\} and Chang, \{Wei Chiao\}",

year = "2013",

month = jun,

doi = "10.3390/molecules18066584",

language = "English",

volume = "18",

pages = "6584--6596",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

TY - JOUR

T1 - Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

AU - Guo, Yuh Cherng

AU - Chang, Che Mai

AU - Hsu, Wen Li

AU - Chiu, Siou Jin

AU - Tsai, Yao Ting

AU - Chou, Yii Her

AU - Hou, Ming Feng

AU - Wang, Jaw Yan

AU - Lee, Mei Hsien

AU - Tsai, Ke Li

AU - Chang, Wei Chiao

PY - 2013/6

Y1 - 2013/6

N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

AB - Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

KW - COX-2

KW - Cell migration

KW - EGF

KW - Indomethacin

UR - https://www.scopus.com/pages/publications/84879611523

UR - https://www.scopus.com/pages/publications/84879611523#tab=citedBy

U2 - 10.3390/molecules18066584

DO - 10.3390/molecules18066584

M3 - Article

C2 - 23736792

AN - SCOPUS:84879611523

SN - 1420-3049

VL - 18

SP - 6584

EP - 6596

JO - Molecules

JF - Molecules

IS - 6

ER -

Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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