Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan

Cheng Hsun Chiu; Lin Hui Su; Yhu Chering Huang; Jui Chia Lai; Hsiu Ling Chen; Tsu Lan Wu; Tzou Yien Lin

doi:10.1128/AAC.01563-06

Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan

Cheng Hsun Chiu, Lin Hui Su, Yhu Chering Huang, Jui Chia Lai, Hsiu Ling Chen, Tsu Lan Wu, Tzou Yien Lin

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.

Original language	English
Pages (from-to)	3404-3406
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	9
DOIs	https://doi.org/10.1128/AAC.01563-06
Publication status	Published - Sept 2007
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.01563-06

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Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan. / Chiu, Cheng Hsun; Su, Lin Hui; Huang, Yhu Chering et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 9, 09.2007, p. 3404-3406.

Research output: Contribution to journal › Article › peer-review

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AU - Chen, Hsiu Ling

AU - Wu, Tsu Lan

AU - Lin, Tzou Yien

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AB - The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.

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Increasing ceftriaxone resistance and multiple alterations of penicillin-binding proteins among penicillin-resistant Streptococcus pneumoniae isolates in Taiwan

Abstract

ASJC Scopus subject areas

UN SDGs

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