TY - JOUR
T1 - Increased subsequent risk of inflammatory bowel disease association in patients with chronic pancreatitis
T2 - a nationwide population-based cohort study
AU - Chen, Yu Long
AU - Hsu, Chin Wang
AU - Cheng, Cheng Chung
AU - Yiang, Giou-Teng
AU - Lin, Chin Sheng
AU - Lin, Cheng Li
AU - Sung, Fung Chang
AU - Liang, Ji An
N1 - Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/6/3
Y1 - 2017/6/3
N2 - Purpose: To investigate the relationship between chronic pancreatitis (CP) and inflammatory bowel disease (IBD) in a large population-based cohort study. Methods: Data was obtained from the Taiwan National Health Insurance Research Database. The cohort study comprised 17,796 patients newly diagnosed with CP between 2000 and 2010 and 71,164 matched controls. A Cox proportional hazards model was used for evaluating the risk of IBD in the CP and comparison cohorts. Results: When examined with a mean follow-up period of 4.87 and 6.04 years for the CP and comparison cohorts, respectively, the overall incidence of IBD was 10.3 times higher in the CP cohort than in the comparison cohort (5.75 vs. 0.56 per 10,000 person-years). Compared with the comparison cohort, the CP cohort exhibited a higher risk of IBD, irrespective of age, sex, and presence or absence of comorbidities. Moreover, the CP cohort was associated with a significantly higher risk of Crohn’s disease (adjusted hazard ratio [aHR] = 12.9, 95% confidence interval [CI] = 5.15–32.5) and ulcerative colitis (aHR = 2.80, 95% CI = 1.00–7.86). Conclusions: This nationwide population-based cohort study revealed a significantly higher risk of IBD in patients with CP compared with control group. Clinicians should notice this association to avoid delayed diagnosis of IBD in patients with CP.
AB - Purpose: To investigate the relationship between chronic pancreatitis (CP) and inflammatory bowel disease (IBD) in a large population-based cohort study. Methods: Data was obtained from the Taiwan National Health Insurance Research Database. The cohort study comprised 17,796 patients newly diagnosed with CP between 2000 and 2010 and 71,164 matched controls. A Cox proportional hazards model was used for evaluating the risk of IBD in the CP and comparison cohorts. Results: When examined with a mean follow-up period of 4.87 and 6.04 years for the CP and comparison cohorts, respectively, the overall incidence of IBD was 10.3 times higher in the CP cohort than in the comparison cohort (5.75 vs. 0.56 per 10,000 person-years). Compared with the comparison cohort, the CP cohort exhibited a higher risk of IBD, irrespective of age, sex, and presence or absence of comorbidities. Moreover, the CP cohort was associated with a significantly higher risk of Crohn’s disease (adjusted hazard ratio [aHR] = 12.9, 95% confidence interval [CI] = 5.15–32.5) and ulcerative colitis (aHR = 2.80, 95% CI = 1.00–7.86). Conclusions: This nationwide population-based cohort study revealed a significantly higher risk of IBD in patients with CP compared with control group. Clinicians should notice this association to avoid delayed diagnosis of IBD in patients with CP.
KW - Chronic pancreatitis
KW - Crohn’s disease
KW - Inflammatory bowel disease
KW - Taiwan National Health Insurance Research Database
KW - Ulcerative colitis
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U2 - 10.1080/03007995.2017.1300143
DO - 10.1080/03007995.2017.1300143
M3 - Article
C2 - 28277863
AN - SCOPUS:85016978003
SN - 0300-7995
VL - 33
SP - 1077
EP - 1082
JO - Current Medical Research and Opinion
JF - Current Medical Research and Opinion
IS - 6
ER -