Increased risk of stroke after trigeminal neuralgia-a population-based follow-up study

Shin Liang Pan, Li Sheng Chen, Ming Fang Yen, Yueh Hsia Chiu, Hsiu Hsi Chen

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background: There are no reports on the risk of stroke after trigeminal neuralgia (TN). The aim of this population-based follow-up study was to investigate whether the occurrence of TN is associated with a higher risk of developing stroke.Methods: A total of 1453 people with at least three ambulatory visits in 2001 with the principal diagnosis of TN were enrolled in the TN cohort. The non-TN cohort consisted of 5812 age- and sex-matched, randomly sampled subjects without TN. The 2-year stroke-free survival rate between the two groups was compared using the Kaplan-Meier method. The Cox proportional hazards regression model was used to estimate the hazard ratio of stroke after adjustment for demographic and clinical covariates.Results: In the TN cohort, 73 patients developed stroke during follow-up, while in the non-TN cohort, 157 subjects suffered a stroke. The crude hazard ratio of stroke for the subjects with TN was 1.86 (95% CI, 1.41-2.45; p-

Original languageEnglish
Pages (from-to)937-942
Number of pages6
Issue number8
Publication statusPublished - Jun 2011


  • cerebrovascular disease
  • risk factors
  • stroke
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Clinical Neurology


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