Increased risk of stroke after septicaemia: A population-based longitudinal study in Taiwan

Jiunn Tay Lee; Wen Ting Chung; Jin Ding Lin; Giia Sheun Peng; Chih Hsin Muo; Che Chen Lin; Chi Pang Wen; I. Kuan Wang; Chun Hung Tseng; Chia Hung Kao; Chung Y. Hsu

doi:10.1371/journal.pone.0089386

Increased risk of stroke after septicaemia: A population-based longitudinal study in Taiwan

Jiunn Tay Lee, Wen Ting Chung, Jin Ding Lin, Giia Sheun Peng, Chih Hsin Muo, Che Chen Lin, Chi Pang Wen, I. Kuan Wang, Chun Hung Tseng, Chia Hung Kao, Chung Y. Hsu

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Inflammation and infection have been noted to increase stroke risk. However, the association between septicaemia and increased risk of stroke remains unclear. This population-based cohort study, using a National Health Insurance database, aimed to investigate whether patients with septicaemia are predisposed to increased stroke risk. The study included all patients hospitalised for septicaemia for the first time between 2000 and 2003 without prior stroke. Patients were followed until the end of 2010 to evaluate incidence of stroke. An age-, gender- and co-morbidities-matched cohort without prior stroke served as the control. Cox's proportional hazards regressions were used to assess differences in stroke risk between groups. Based on hazard ratios (HRs), patients with septicaemia had greater stroke risk, especially in the younger age groups (age 0.05). Haemorrhagic stroke was the dominant type (ischaemic stroke: HR = 1.20, 95% CI: 1.06-1.37, p

Original language	English
Article number	e89386
Journal	PLoS One
Volume	9
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0089386
Publication status	Published - Feb 21 2014
Externally published	Yes

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry,Genetics and Molecular Biology
General Medicine

Access to Document

10.1371/journal.pone.0089386

Cite this

@article{e2912ad204334599aed5074c9bc73428,

title = "Increased risk of stroke after septicaemia: A population-based longitudinal study in Taiwan",

abstract = "Inflammation and infection have been noted to increase stroke risk. However, the association between septicaemia and increased risk of stroke remains unclear. This population-based cohort study, using a National Health Insurance database, aimed to investigate whether patients with septicaemia are predisposed to increased stroke risk. The study included all patients hospitalised for septicaemia for the first time between 2000 and 2003 without prior stroke. Patients were followed until the end of 2010 to evaluate incidence of stroke. An age-, gender- and co-morbidities-matched cohort without prior stroke served as the control. Cox's proportional hazards regressions were used to assess differences in stroke risk between groups. Based on hazard ratios (HRs), patients with septicaemia had greater stroke risk, especially in the younger age groups (age 0.05). Haemorrhagic stroke was the dominant type (ischaemic stroke: HR = 1.20, 95% CI: 1.06-1.37, p",

author = "Lee, {Jiunn Tay} and Chung, {Wen Ting} and Lin, {Jin Ding} and Peng, {Giia Sheun} and Muo, {Chih Hsin} and Lin, {Che Chen} and Wen, {Chi Pang} and Wang, {I. Kuan} and Tseng, {Chun Hung} and Kao, {Chia Hung} and Hsu, {Chung Y.}",

year = "2014",

month = feb,

day = "21",

doi = "10.1371/journal.pone.0089386",

language = "English",

volume = "9",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "2",

}

TY - JOUR

T1 - Increased risk of stroke after septicaemia

T2 - A population-based longitudinal study in Taiwan

AU - Lee, Jiunn Tay

AU - Chung, Wen Ting

AU - Lin, Jin Ding

AU - Peng, Giia Sheun

AU - Muo, Chih Hsin

AU - Lin, Che Chen

AU - Wen, Chi Pang

AU - Wang, I. Kuan

AU - Tseng, Chun Hung

AU - Kao, Chia Hung

AU - Hsu, Chung Y.

PY - 2014/2/21

Y1 - 2014/2/21

N2 - Inflammation and infection have been noted to increase stroke risk. However, the association between septicaemia and increased risk of stroke remains unclear. This population-based cohort study, using a National Health Insurance database, aimed to investigate whether patients with septicaemia are predisposed to increased stroke risk. The study included all patients hospitalised for septicaemia for the first time between 2000 and 2003 without prior stroke. Patients were followed until the end of 2010 to evaluate incidence of stroke. An age-, gender- and co-morbidities-matched cohort without prior stroke served as the control. Cox's proportional hazards regressions were used to assess differences in stroke risk between groups. Based on hazard ratios (HRs), patients with septicaemia had greater stroke risk, especially in the younger age groups (age 0.05). Haemorrhagic stroke was the dominant type (ischaemic stroke: HR = 1.20, 95% CI: 1.06-1.37, p

AB - Inflammation and infection have been noted to increase stroke risk. However, the association between septicaemia and increased risk of stroke remains unclear. This population-based cohort study, using a National Health Insurance database, aimed to investigate whether patients with septicaemia are predisposed to increased stroke risk. The study included all patients hospitalised for septicaemia for the first time between 2000 and 2003 without prior stroke. Patients were followed until the end of 2010 to evaluate incidence of stroke. An age-, gender- and co-morbidities-matched cohort without prior stroke served as the control. Cox's proportional hazards regressions were used to assess differences in stroke risk between groups. Based on hazard ratios (HRs), patients with septicaemia had greater stroke risk, especially in the younger age groups (age 0.05). Haemorrhagic stroke was the dominant type (ischaemic stroke: HR = 1.20, 95% CI: 1.06-1.37, p

UR - http://www.scopus.com/inward/record.url?scp=84896798010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896798010&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0089386

DO - 10.1371/journal.pone.0089386

M3 - Article

C2 - 24586739

AN - SCOPUS:84896798010

SN - 1932-6203

VL - 9

JO - PLoS One

JF - PLoS One

IS - 2

M1 - e89386

ER -

Increased risk of stroke after septicaemia: A population-based longitudinal study in Taiwan

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this