TY - JOUR
T1 - Increased risk of preterm births among women with uterine leiomyoma
T2 - A nationwide population-based study
AU - Chen, Yi Hua
AU - Lin, Herng Ching
AU - Chen, Shu Fen
AU - Lin, Hsiu Chen
PY - 2009/12
Y1 - 2009/12
N2 - BACKGROUND: Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma. METHODS: This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers. RESULTS: Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78, P < 0.001) and SGA infants (19.00 versus 17.28, P = 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P < 0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95 CI 1.19-1.46) and 1.16 (95 CI 1.08-1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P = 0.022). CONCLUSIONS: We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy.
AB - BACKGROUND: Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma. METHODS: This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers. RESULTS: Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78, P < 0.001) and SGA infants (19.00 versus 17.28, P = 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P < 0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95 CI 1.19-1.46) and 1.16 (95 CI 1.08-1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P = 0.022). CONCLUSIONS: We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy.
KW - Birthweight
KW - Pregnancy
KW - Preterm birth
KW - Small for gestational age
KW - Uterine leiomyoma
UR - http://www.scopus.com/inward/record.url?scp=72949119338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72949119338&partnerID=8YFLogxK
U2 - 10.1093/humrep/dep320
DO - 10.1093/humrep/dep320
M3 - Article
C2 - 19740897
AN - SCOPUS:72949119338
SN - 0268-1161
VL - 24
SP - 3049
EP - 3056
JO - Human Reproduction
JF - Human Reproduction
IS - 12
ER -